On the morning of August 30, the 4th session of the Chemical Biology High-end Forum was held by the State Key Laboratory of Medicinal Chemical Biology. Carlos J. Bustamante, a member of the National Academy of Sciences and a professor at the University of California at Berkeley, and Chen Wei, a winner of National Outstanding Youth Foundation and a professor at Zhejiang University, were invited as keynote speakers. The forum was chaired by Prof. Yu Zhongbo, with Prof. Hanbin Mao from Kent State University, Prof. Qi Zhi from Peking University, and Prof. Ma Jie from Sun Yat-sen University also participating. The forum was conducted online, attracting about 200 students and teachers from inside and outside the university. Meanwhile, the forum was also broadcast live to the public through Research Cloud and other platforms, with a total of more than 40,000 viewers.

Professor Carlos J. Bustamante gave a presentation titled "Division of Labor Among the Subunits of a DNA Packaging Viral ATPases and its Mechanism of Translocation", to systematically introduce the mutual coordination among ATPase subunits and the mechanism of translocation. Prof. Carlos J. Bustamante explained in his presentation the mechanochemical transduction of molecular motors, where ATP hydrolysis and ADP release occur during the cycle and the division of labor responsible for these processes. This presentation graphically explained the factors that determine the sudden length increase and the profound mechanism of translocation.

Prof. Chen Wei introduced a series of his works on dynamic mechanochemical regulation and intervention in infection and immune membrane receptor recognition. He introduced the biofilm mechano probe system, an ultrastable single-molecule force spectroscopy technology, the mechanism of membrane receptor recognition dynamics and mechanochemical regulation and intervention strategies, the exploration of the mechanistic regulation mechanism of coronavirus spike protein recognition and activation from both infection and immunity, and the development and application of single-cell technology to study the systemic immunity of various diseases.