Research Interest：
1. Mitochondria function and innate immunity
2. Protein ubiquitination regulation with diseases
3. Golgi dynamic regulation
Education History：
1992-1996，College of Chemistry, Inner Mongolia Minzu University,Bachelor of Chemistry
1996-1999，College of Chemistry, Huazhong University of Science and Technology，Master of Bioorganic
1999-2003，College of Life Science & Technology, Huazhong University of Science and Technology，Doctor of Biomedical Engineering
Scientific Achievements & Selected Publications
1. Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen L, Liu Q, Luo Q, Zhang C, Long Y,Su J, Wang Y, Li Z, Suan J, Chen G, Li Y, Liao X, Shang Y, Hu G, Chen Q, Zhu Y*. NRF1-mediated Mitochondrial Biogenesis Antagonizes Innate Antiviral Immunity. EMBO Journal, 2023: e113258.
2. Chen L, Zhang Q, Meng Y, Zhao T, Mu C, Fu C, Deng C, Feng J, Du S, Liu W, Geng G, Ma K, Cheng H, Liu Q, Luo Q, Zhang J, Wang H, Liu Y, Lin J*, Chen G, LAM Sin Man, Shui G, Zhu Y*, Chen Q*. Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function. EMBO reports 2023, 24(4):e54731.
3. Luo Q, Liu Q, Cheng H, Wang J, Zhao T, Zhang J, Mu C, Meng Y, Chen L, Zhou C, Meng Y, Lei H, Yang J, Chen G, Li Y, Chen Q*, Zhu Y*: Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses. Cell Reports 2022, 40(7):111195.
4. Liu Q, Luo Q, Feng J, Zhao Y, Ma B, Cheng H, Zhao T, Lei H, Mu C, Chen L, Zhao Y, Meng Y, Zhang J, Long Y,Su J, Chen G, Li Y,Gang Hu, Chen Q, Zhu Y*. Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression. eLife 2022, 11.
5. Geng G, Liu J, Xu C, Pei Y, Chen L, Mu C, Wang D, Gao J, Li Y, Liang J,Zhao T, Zhang C, Zhou J, Chen Q, Zhu Y*, Shi L*. Receptor-mediated mitophagy regulates EPO production and protects against renal anemia. eLife 2021, 10.
6. Ma K, Zhang Z, Chang R, Cheng H, Mu C, Zhao T, Chen L, Zhang C, Luo Q, Lin J*, Zhu Y*, Chen Q*, Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate. Cell Death & Differentiation 2020, 27(3):1036-1051.
7. Ma B#, Cheng H#, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Ma K, Han J, Chen L, Zhu Y*, Chen Q*: The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression. Nature Communications 2019,10(1):1034
8. Zhou C, Ma K, Gao R, Mu C, Chen L, Liu Q, Luo Q, Feng D, Zhu Y*, Chen Q*. Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy. Cell Research 2017, 27(2):184-201.
9. Ma B#, Cheng H, Gao R, Mu C, Chen L, Wu S, Chen Q, Zhu Y*. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-beta signalling pathways. Nature Communications 2016, 7:11123.
10. Song P, Li S, Wu H, Gao R, Rao G, Wang D, Chen Z, Ma B, Wang H,Sui N, Deng, H, Zhang Z, Tang T, Tan Z, Han, Z. Lu T, Zhu Y*, Chen Q*: Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. Protein & cell 2016, 7(2):114-129.
11. Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, Gao R, Zhou C, Cao L, Liu J, Zhu Y*, Chen Q*, Wu S*. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nature Cell Biology 2015, 17(1):95-103.
12. Li J, Qi W, Chen G, Feng D, Liu J, Ma B, Zhou C, Mu C, Zhang W, Chen Q*, Zhu Y*. Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy. Autophagy 2015, 11(8):1216-1229.
13. Chen G, Han Z, Feng D, Chen Y, Chen L, Wu H, Huang L, Zhou C, Cai X, Fu C, Duan L, Wang X, Liu X, Shen Y, Zhu Y*, Chen Q*: A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Molecular Cell 2014, 54(3):362-377.
14. Zhu Y#, Li M#, Wang X, Jin H, Liu S, Xu J*, Chen Q*. Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release. Cell Research 2012,22: 127-1412
15. Zhu Y#, Zhao L#, Liu L, Gao P, Tian W, Wang X, Jin H, Xu H, Chen Q*. Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein & Cell 2010, 1(5):468-477.
