Research Interest：
Function and regulation of transposons in pluripotent stem cells
Education History：
2008-2013: Ph.D., National University of Singapore, Singapore
Publications:
1. Zhao, X., Li, X.M., Sun, H.Y., Zhao, X., Gao, T.T., Shi, P.P., Chen, F.Q., Liu, L. and Lu, X. Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells. (2023) Nucleic Acids Research. (IF: 19.16)
2. Zhao, N., Yin, G., Liu, C., Zhang, W., Shen, Y., Wang, D., Lin, Z., Yang, J., Mao, J., Guo, R., Zhang, Y., Wang, F., Zhe Liu, Z. #, Lu, X.#, Liu, L#. (2023) Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells. Cell Discovery;9(1):45. (#, corresponding; IF: 38)
3. Chen, F., Zhang, W., Xie, D., Gao, T., Dong, Z. and Lu, X. (2020) Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters. Nucleic Acids Research, 48, 10211-10225. (IF: 19.16)
4. Zhang, W., Chen, F., Chen, R., Xie, D., Yang, J., Zhao, X., Guo, R., Zhang, Y., Shen, Y., Goke, J., Liu, L.#, Lu, X. # (2019) Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes. Nucleic Acids Research, 47, 8485-8501. (IF: 19.16)
5. Zhao, X., Shen, J., Zhao, X., Zhang M., Feng, X., Zhang, W., Lu, X. (2022) PIM3-AMPK-HDAC4/5 axis restricts MuERVL-marked 2-cell-like state in embryonic stem cells. Stem Cell Reports; 17(10):2256-2271. (IF: 7.29)
6. Chen, F., Li, X., Feng, X., Gao, T., Zhang, W., Cheng, Zhi., Zhao, Xuan., Chen, R.Lu, X. (2022) Long noncoding RNA Lx8-SINE B2 interacts with Eno1 to regulate self-renewal and metabolism of embryonic stem cells. Stem Cells; 40(12):1094-1106. (IF: 5.84)
7. Lu, X. (2023) Regulation of endogenous retroviruses in murine embryonic stem cells and early embryos. Journal of Molecular Cell Biology, Accepted. (IF: 8.18)
8. Zhang, M., Zhao, X., Feng, X., Hu, X., Zhao, X., Lu, W., Lu, X. (2022) Histone chaperone HIRA complex regulates retrotransposons in embryonic stem cells. Stem Cell Research & Therapy, 13(1):137. (IF: 8.08)
9. Xinyi Lu, Friedrich Sachs, LeeAnn Ramsay,Pierre-Etienne Jacques, Jonathan Goeke, Guillaume Bourque#& Huck-Hui Ng#. The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity. Nature Structural & Molecular Biology. 2014;21(4):423-5.
10. Xinyi Lu*, Jonathan Goeke*, Friedrich Sachs, Pierre-Etienne Jacques, Hongqing Liang, Bo Feng, Guillaume Bourque, Paula A. Bubulya, Huck-Hui Ng#. SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells. Nature Cell Biology. 2013 Oct;15(10):1141-52.
