Research Interest：
pathological mechanism of neurodegenerative diseases and drug development
Education：
1991-1995， College of Chemistry, University of Science and Technology Beijing，Bachelor of Chemistry
1995-2000，Institute of Biophysics, Chinese Academy of Science, Doctor of Molecular Biology
Working experience:
2000.5-2001.4 Brandeis University，Postdoctoral Fellow
2001.5-2006.7 University of Chicago, Research Associate
2006.7-2006.12 University of Chicago, Research Assistant Professor
2006.12-present Nankai University, Professor
Selected Publications
1. Chen, X., Wang, Y., Li, Y., Lu, X., Chen, J., Li, M., Wen, T., Liu, N., Chang, S., Zhang, X., Yang, X.*, Shen, Y.* (2022) Cryo-EM structure of the human TACAN channel in a closed state. Cell Rep. 38(9): 110445.
2. Wen, T., Wang, Z., Chen, X., Ren, Y., Lu, X., Xing, Y., Lu, J., Chang, S., Zhang, X., Shen, Y.*, Yang, X.* (2021) Structural Basis for Activation and Allosteric Modulation of Full-length Calcium Sensing Receptor. Sci. Adv. 7:eabg1483
3. Ren, Y., Wen, T., Xi, Z., Li, S., Lu, J., Zhang, X., Yang, X.*, Shen, Y.* (2020) Cryo-EM structure of the calcium homeostasis modulator 1 channel. Sci. Adv., 6, eaba8161.
4. Liu, M., Wang, D., Li, Y., Li, X., Zong, G., Fei, S., Yang, X., Lin, J., Wang, X.*, Shen, Y.* (2020) Crystal Structures of the C-glycosyltransferase UGT708C1 from Buckwheat (Fagopyrum esculentum) provide insights into the mechanism of C-glycosylation. Plant Cell, 32(9):2917-2931.
5. Liu, X., Wu, G., Yu, Y., Chen, X., Ji, R., Lu, J., Li, X., Zhang, X., Yang, X.*, Shen, Y.* (2019) Molecular understanding of calcium permeation through the open Orai channel. PLOS Biol., 17(4):e3000096.
6. Xing, Y., Wang, M., Wang, J., Nie, Z., Wu, G., Yang, X.*, Shen, Y.* (2019) Dimerization of MICU proteins controls Ca2+ influx through the mitochondrial Ca2+ uniporter. Cell Report. 26(5):1203-1212.
7. Li, X., Wu, G., Yang, Y., Fu, S., Liu, X., Kang, H., Yang. X.*, Su, X.*, Shen, Y.* (2017) Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers. Nat. Comm., 8(1), 1042.
8. Wang, L., Yang, X., Wang, Z., Liu, Y., Feng, J. Zhu, Y., Shen, Y.* (2014) Structural and Mechanistic Insights into MICU1 Regulation of Mitochondrial Calcium Uptake. EMBO J, 33(6), 594-604.
9. Yang, X., Jin, H., Cai, X., Li, S., Shen, Y.* (2012) Structural and Mechanistic Insights into the Activation of STIM1, Proc. Natl. Acad. Sci. USA, 109(15), 5657–5662.
10. Shen Y., Joachimiak A., Rosner M.R., Tang W.-J. (2006) Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature, 443，870-874.
