Research Interest： Nanochaperones for the regulation of protein folding and homeostasis, anti-tumor and anti-drug-resistant bacterial nanomedicines.
Education History：
1980-1984, Department of Chemistry, Hebei University，Bachelor of Chemistry
1987-1993， Changchun Institute of Applied Chemistry, Chinese Academy Sciences，Doctor of Polymer Chemistry and Physics
Honors and Awards
2018, Wiley Biosciences Award
2019, Outstanding Contribution Award for Biomedical Polymer Materials
2022, The First Prize in Tianjin Natural Science
Scientific Achievements & Selected Publications
1. Yong Liu, Lin-Qi Shi*, Lin-Zhu Su, Henny C. van der Mei, Paul C. Jutte, Yi-Jin Ren, Henk J. Busscher*, Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control. Chem. Soc. Rev., 2019, 48, 428–446.
2. Yang Liu#, Juan-Juan Du#, Ming Yan, Moyin Lau, Jay Hu, Hui Han, Ottoo Yang, Sheng Liang, Wei Wei, Hui Wang, Jian-min Li, Xin-Yuan Zhu, Lin-Qi Shi*, Wei Chen*, Cheng Ji*, Yun-Feng Lu*, Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication. Nat. Nanotechnol., 2013, 8, 187–192.
3. Fei-He Ma, Chang Li, Yang Liu* and Lin-Qi Shi*, Mimicking Molecular Chaperones to Regulate Protein Folding. Adv. Mater., 2020, 32, 18059453.
4. Zhen-Kun Zhang, Ru-Jiang Ma, Lin-Qi Shi, Cooperative Macromolecular Self-Assembly toward Polymeric Assemblies with Multiple and Bioactive Functions. Accounts Chem. Res., 2014, 47, 1426–1437.
5. Xiao-Hui Wu, Fei-He Ma*, Bin-Bin Pan, Yan-Li Zhang, Lin Zhu, Fei Deng, Lin-Lin Xu, Yu Zhao, Xu Yin, Hai-Hong Niu, Xun-Cheng Su*, Lin-Qi Shi*, Tailoring a Nanochaperone to Regulate alpha-Synuclein Assembly. Angew. Chem. Int. Ed., 2022, 61, e202200192.
6. Fei-He Ma#, Xiao-Hui Wu#, Ang Li, Lin-Lin Xu, Ying-Li An, Lin-Qi Shi*, A Balance Between Capture and Release: How Nanochaperones Regulate Refolding of Thermally Denatured Proteins. Angew. Chem. Int. Ed., 2021, 60, 10865–10870.
7. Da-Yuan Wang, Guang Yang, Henny C. van Der Mei*, Yi-Jin Ren, Henk J. Busscher*, Lin-Qi Shi*, Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection Sites. Angew. Chem. Int. Ed., 2021, 60, 17714–17719.
8. Fan Huang, Jian-Zu Wang, Ao-Ting Qu, Liang-Liang Shen, Jin-Jian Liu, Jian-Feng Liu, Zhen-Kun Zhang, Ying-Li An, Lin-Qi Shi*, Maintenance of Amyloid beta Peptide Homeostasis by Artificial Chaperones Based on Mixed-Shell Polymeric Micelles, Angew. Chem. Int. Ed., 2014, 53, 8985–8990.
9. Shuang Tian, Lin-Zhu Su, Yong Liu, Jing-Jing Cao, Guang Yang, Yi-Jin Ren, Fan Huang, Jian-Feng Liu*, Ying-Li An, Henny C. van der Mei*, Henk J. Busscher*, Lin-Qi Shi*, Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms-An intravital imaging study in mice. Sci. Adv., 2020, 6, eabb111233.
10. Lin-Lin Xu, Yu-Xun Ding, Fei-He Ma, Yue Chen, Gui-Dong Chen, Lin-Zhu, Jia-Fu Long, Ru-Jiang Ma, Yang Liu, Jian-Feng Liu, Fan Huang*, Lin-Qi Shi*, Engineering a pathological tau-targeted nanochaperone for selective and synergetic inhibition of tau pathology in Alzheimer's Disease, Nano Today, 2022, 43, 101388.
