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孙宝发教授Bao-Fa Sun
Doctor degree, professor, State laboratory of Medical Chemical Biology and College of Life Sciences, graduated from Institute of Zoology, University of Chinese Academy of Sciences.
Special Talent:
Address: Institute of Molecular Biology #402, Nankai University, 94 Weijin Road, Tianjin 300071, China
Telephone:
Email: sunbf@nankai.edu.cn
Research Group Website: https://sky.nankai.edu.cn/sbf/list.htm

Research Interest: Bioinformatics analysis and functional study based on single-cell transcriptomics and epigenomics

Education History:

2002.09 - 2006.06, College of Life Sciences, Hunan University of Science and Technology, Bachelor of Science

2006.09 - 2009.06, College of Science, Shantou University, Master of Science

2009.09 - 2013.01, Institute of Zoology, University of Chinese Academy of Sciences, Doctor of Science

Honors and Awards:

1.     Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences;

2.     “m6A modulates haematopoietic stem and progenitor cell specification”, published in Nature, was named the top ten advances in life science research in China in 2017

3.     “5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader”, published in Cell Research, won Sanofi-Cell Research outstanding paper award of 2017

4.     “5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader”and “Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase” were selected as the outstanding scientific and technological paper of the 3rd China Association for Science and Technology

Scientific Achievements & Selected Publications:

1.     Chunxia Zhang#, Yusheng Chen#, Baofa Sun#, Lu Wang#, Ying Yang#, Dongyuan Ma, Junhua Lv, Jian Heng, Yanyan Ding, Yuanyuan Xue, Xinyan Lu, Wen Xiao, Yun-Gui Yang*, Feng Liu*. m6A modulates haematopoietic stem and progenitor cell specification. Nature 2017, 549, 273-276

2.     Shoubao Ma#, Baofa Sun#, Songqi Duan#, Jingjing Han#, Tasha Barr, Jianying Zhang, Marc B. Bissonnette, Marcin Kortylewski, Chuan He, Jianjun ChenMichael A. Caligiuri*, Jianhua Yu*. YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8(+) T cells. Nature Immunology 2023, 24, 255-266

3.     Xin Chen#, Ang Li#, Bao-Fa Sun#, Ying Yang#, Ya-Nan Han#, Xun Yuan#, Ri-Xin Chen, Wen-Su Wei, Yanchao Liu, Chun-Chun Gao, Yu-Sheng Chen, Mengmeng Zhang, Xiao-Dan Ma, Zhuo-Wei Liu, Jun-Hang Luo, Cong Lyu, Hai-Lin Wang, Jinbiao Ma, Yong-Liang Zhao, Fang-Jian Zhou, Ying Huang*, Dan Xie*, Yun-Gui Yang*. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nature Cell Biology 2019, 21, 978-990

4.     Jun-Ya Peng#, Bao-Fa Sun#, Chuan-Yuan Chen#, Jia-Yi Zhou#, Yu-Sheng Chen#, Hao Chen, Lulu Liu, Dan Huang, Jialin Jiang, Guan-Shen Cui, Ying Yang, Wenze Wang, Dan Guo, Menghua Dai, Junchao Guo, Taiping Zhang, Quan Liao, Yi Liu, Yong-Liang Zhao, Da-Li Han#, Yupei Zhao*, Yun-Gui Yang*, Wenming Wu*. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. Cell Research 2019, 29, 725-738

5.     Yihao Liu#, Minmin Shi#, Xingfeng He#, Yizhi Cao, Pengyi Liu, Fanlu Li, Siyi Zou, Chenlei Wen, Qian Zhan, Zhiwei Xu, Jiancheng Wang*, Baofa Sun* and Baiyong Shen*. LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma. Journal of Hematology & Oncology 2022, 15, 52

6.     Yaqian Li#, Qingyang Zhang#, Baofa Sun#, Yidi Ma, Ye Zhang, Min Wang , Congcong Ma , Honghui Shi , Zhijing Sun , Juan Chen , Yun-Gui Yang*, Lan Zhu* . Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse, Nature Communications 2021, 12, 87

7.     Shiming Peng#, Wen Xiao#, Dapeng Ju#, Baofa Sun#, Nannan Hou, Qianlan Liu, Yanli Wang, Haijiao Zhao, Chunchun Gao, Song Zhang, Ran Cao, Pengfei Li, Huanwei Huang, Yongfen Ma, Yankai Wang, Weiyi Lai, Zhixiong Ma, Wei Zhang, Song Huang, Hailin Wang, Zhiyuan Zhang, Liping Zhao, Tao Cai, Yong-Liang Zhao, Fengchao Wang, Yongzhan Nie, Gang Zhi, Yun-Gui Yang*, Eric Erquan Zhang*, Niu Huang*. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Science Translational Medicine 2019, 11, eaau7116

8.     Rong Wu#, Ang Li#, Baofa Sun#, Jian Guang Sun#, Jinhua Zhang#, Ting Zhang#, Yusheng Chen, Yujie Xiao, Yuhao Gao, Qingyang Zhang, Jun Ma, Xin Yang, Yajin Liao, Wei-Yi Lai, Xiaolong Qi, Shukun Wang, Yousheng Shu, Hai-Lin Wang, Fengchao Wang*, Yun-Gui Yang*, Zengqiang Yuan*. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination. Cell Research 2019, 29, 23-41

9.     Xin Tian#, Baofa Sun#, Chuanyuan Chen#, Chunchun Gao#, Ji Zhang#, Xingyu Lu#, Linchen Wang, Xiangnan Li, Yurong Xing, Rujuan Liu, Xiao Han, Zheng Qi, Xiaojian Zhang, Chuan He, Dali Han*, Yun-Gui Yang*, Quancheng Kan*. Circulating Tumor DNA-hydroxymethylcytosine as novel diagnostic biomarkers for esophageal cancer. Cell Research 2018, 28, 597-600

10. Xin Yang#, Ying Yang#, Bao-Fa Sun#, Yu-Sheng Chen#, Jia-Wei Xu#, Wei-Yi Lai#, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Hui-Ying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chun-Min Huang, Niu Huang, Gui-Bin Jiang, Yong-Liang Zhao, Hai-Lin Wang*, Ying-Pu Sun* and Yun-Gui Yang*. 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader. Cell Research 2017, 27, 606-625

11. Ang Li#, Yu-Sheng Chen#, Xiao-Li Ping, Xin Yang, Wen Xiao, Ying Yang, Hui-Ying Sun, Qin Zhu, Poonam Baidya, Xing Wang, Devi Prasad Bhattarai, Yong-Liang Zhao, Bao-Fa Sun*, Yun-Gui Yang*. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation. Cell Research 2017, 27, 444-447

12. Kai Xu#, Ying Yang#, Gui-Hai Feng#, Bao-Fa Sun#, Jun-Qing Chen#, Yu-Fei Li, Yu-Sheng Chen, Xin-Xin Zhang, Chen-Xin Wang, Li-Yuan Jiang, Chao Liu, Ze-Yu Zhang, Xiu-Jie Wang, Qi Zhou*, Yun-Gui Yang*, Wei Li*. Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation. Cell Research 2017, 27, 1100-1114

13. Wen Xiao#, Samir Adhikari#, Ujwal Dahal#, Yu-Sheng Chen#, Ya-Juan Hao#, Bao-Fa Sun#, Hui-Ying Sun, Ang Li, Xiao-Li Ping, Wei-Yi Lai, Xing Wang, Hai-Li Ma, Chun-Min Huang, Ying Yang, Niu Huang, Guibin Jiang, Hai-Lin Wang, Qi Zhou, Xiu-Jie Wang, Yong-Liang Zhao, Yun-Gui Yang*. Nuclear m6A reader YTHDC1 regulates mRNA splicing. Molecular Cell 2016, 61, 507-519

14. Xiao-Li Ping#, Bao-Fa Sun#, Lu Wang#, Wen Xiao#, Xin Yang, Wen-Jia Wang, Samir Adhikari, Yue Shi, Ying Lv, Yu-Sheng Chen, Xu Zhao, Ang Li, Ying Yang, Ujwal Dahal, Xiao-Min Lou, Xi Liu, Jun Huang, Wei-Ping Yuan, Xiao-Fan Zhu, Tao Cheng, Yong-Liang Zhao, Xinquan Wang, Jannie M Rendtlew Danielsen, Feng Liu*, Yun-Gui Yang*. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Research 2014, 24, 177-189

15. Xu Zhao#, Ying Yang#, Bao-Fa Sun#, Yue Shi#, Xin Yang, Wen Xiao, Ya-Juan Hao, Xiao-Li Ping, Yu-Sheng Chen, Wen-Jia Wang, Kang-Xuan Jin, Xing Wang, Chun-Min Huang, Yu Fu, Xiao-Meng Ge, Shu-Hui Song, Hyun Seok Jeong, Hiroyuki Yanagisawa, Yamei Niu, Gui-Fang Jia, Wei Wu, Wei-Min Tong, Akimitsu Okamoto, Chuan He, Jannie M Rendtlew Danielsen, Xiu-Jie Wang, Yun-Gui Yang*. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Research 2014, 24, 1403-1419