Research Interest：

·     Tissue engineering of vascular grafts

·     Vascular injury repair strategies

·     Early detection and diagnosis of atherosclerosis

Education History：

2003/09–2007/06, college of Life Sciences, Zhengzhou University，Bachelor of Biotechnology.

2007/09–2010/06, college of Life Sciences, NanKai University, Master of Biochemistry and molecular biology.

2010/09–2013/06, college of Life Sciences, NanKai University, Doctor of Biochemistry and molecular biology.

Honors and Awards

1.     2021-First National Post-Doctoral Innovation and Entrepreneurship Competition. Bronze Prize. Overall Ranking: 1/3.

2.     2019-Natural Science Foundation of Tianjin, China. First Prize. Overall Ranking: 8/11.

3.     2018-Natural Science Foundation of Tianjin, China. Second Prize. Overall Ranking: 5/8.

4.     2018-National Congress on Materials for Regenerative Medicine of China. Young Scholar Award. Overall Ranking: 1/1.

5.     2019-Outstanding Young Researcher of the College of Life Sciences, Nankai University, China. Overall Ranking: 1/1.

6.     2021-Excellent Undergraduate Innovation and Scientific Research Award, Nankai University. Third Prize. My role: supervisor.

Scientific Achievements & Selected Publications

1.       Hongyu Yan#, Quhan Cheng#, Jianghua Si, Songdi Wang, Ye Wan, Xin Kong, Ting Wang, Wenting Zheng, Muhammad Rafique, Xiaofeng Li, Ju He, Adam C. Midgley*, Yi Zhu, Kai Wang*, Deling Kong. Functionalization of in vivo tissue-engineered living biotubes enhance patency and endothelization without the requirement of systemic anticoagulant administration. Bioactive Materials. 2023, 26: 292-305. (*corresponding author)

2.       Ziqi Huang#, Yuwen Zhang#, Ruihua Liu, Yi Li, Muhammad Rafique, Adam C. Midgley, Ye Wan, Hongyu Yan, Jianghua Si, Ting Wang, Cuihong Chen, Ping Wang, Muhammad Shafiq, Jia Li, Lili Zhao, Deling Kong, Kai Wang*. Cobalt loaded electrospun poly(ε-caprolactone) grafts promote antibacterial activity and vascular regeneration in a diabetic rat model. Biomaterials. 2022, 291, 121901. (*corresponding author)

3.       Yan Zhang#, Ke Xu#, Dengke Zhi#, Mengyuan Qian, Kaizheng Liu, Qizhi Shuai, Zheng Qin, Jinghui Xie, Kai Wang*, Jun Yang*. Improving vascular regeneration performance of electrospun poly(ε‑Caprolactone) vascular grafts via synergistic functionalization with VE-Cadherin/VEGF. Advanced Fiber Materials. 2022, 4(6): 1685-1702. (*corresponding author)

4.       Siyang Liu, Liying Yao, Yumeng Wang, Yi Li, Yanju Jia, Yueyue Yang, Na Li, Yuanjing Hu, Deling Kong, Xianhao Dong*, Kai Wang*, Meifeng Zhu*. Immunomodulatory hybrid micro-nanofiber scaffolds enhance vascular regeneration. Bioactive Materials. 2023, 21: 464-482. (*corresponding author)

5.       Fei Wang#, Kang Qin#, Kai Wang#, He Wang#, Qi Liu, Meng Qian, Shang Chen, Yijin Sun, Jingli Hou, Yongzhen Wei, Yanhua Hu, Zongjin Li, Qingbo Xu*, and Qiang Zhao*. Nitric oxide improves regeneration and prevents calcification in bio-hybrid vascular grafts via regulation of vascular stem/progenitor cells. Cell Reports. 2022, 39(12): 110981. (#co-first author)

6.       Jing Zhao#, Yi Li#, Meiyu Wang#, Xumin Chen, Deling Kong, Kai Wang*, Yakai Feng*. Oligoglycine and Fluoropolymer Functionalized Enzyme-Responsive Gene Delivery Surface for Rapid in Situ Endothelialization of Vascular Grafts. Applied Materials Today. 2022, 27: 101476. (*corresponding author)

7.       Quhan Cheng#, Muhammad Shafiq#,*, Muhammad Rafique, Li Shen*, Xiumei Mo, Kai Wang*. Extracellular Matrix and Nitric Oxide Based Functional Coatings for Vascular Stents. Engineered Regeneration. 2022, 3(2): 149-153. (*corresponding author)

8.       Dengke Zhi, Quhan Cheng, Adam C. Midgley, Qiuying Zhang, Tingting Wei, Yi Li, Ting Wang, Tengzhi Ma, Muhammad Rafique, Shuang Xia, Yuejuan Cao, Yangchun Li, Jing Li, Yongzhe Che, Meifeng Zhu*, Kai Wang*, Deling Kong*. Mechanically reinforced biotubes for arterial replacement and arteriovenous grafting inspired by architectural engineering. Science Advances. 2022, 8(11): eabl3888. (*corresponding author)

9.       Qiqi Sun#, Jianghua Si#, Lili Zhao#, Tingting Wei, Ting Wang, Feiyi Li, Yi Li, Muhammad Shafiq, Lili Wang, Ruihua Liu*, Dengke Zhi*, Kai Wang*. Direct thrombin inhibitor-bivalirudin improved the hemocompatibility of electrospun polycaprolactone vascular grafts. Composites Part B: Engineering. 2022, 234: 109702. (*corresponding author)

10.   Kai Wang#, Heqi Gao#, Yuwen Zhang, Hongyu Yan, Jianghua Si, Xingyan Mi, Shuang Xia, Xuequan Feng, Dingbin Liu, Deling Kong, Ting Wang* and Dan Ding*. Highly bright AIE nanoparticles by regulating the substituent of rhodanine for precise early detection of atherosclerosis and drug Screening. Advanced Materials. 2022, 34(9): 2106994. (#co-first author)

11.   Qiqi Sun#, Zefeng Shen#, Xiao Liang, Yingxu He, Deling Kong, Adam C. Midgley* and Kai Wang*. Progress and Current Limitations of Materials for Artificial Bile Duct Engineering. Materials. 2021, 14(23): 7468. (*corresponding author)

12.   Jiaying Zhou#, Meiyu Wang#, Tingting Wei#, Lingchuang Bai, Jing Zhao, Kai Wang*, and Yakai Feng*. Endothelial cell-mediated gene delivery for in situ accelerated endothelialization of a vascular graft. ACS Applied Materials &Interfaces. 2021, 13(14): 16097-16105. (*corresponding author)

13.   Muhammad Rafique#, Tingting Wei#, Qiqi Sun, Adam C. Midgley, Ziqi Huang, Ting Wang, Muhammad Shafiq, Dengke Zhi, Jianghua Si, Hongyu Yan, Deling Kong, Kai Wang*. The effect of hypoxia-mimicking responses on improving the regeneration of artificial vascular grafts. Biomaterials. 2021, 271: 120746. (*corresponding author)

14.   Hongyu Yan#, Xingyan Mi#, Adam C. Midgley, Xinchen Du, Ziqi Huang, Tingting Wei, Ruihua Liu, Tengzhi Ma, Dengke Zhi, Dashuai Zhu, Ting Wang, Guowei Feng, Ying Zhao, Weiye Zhang, Ju He, Meifeng Zhu*, Deling Kong*, and Kai Wang*. Targeted Repair of Vascular Injury by Adipose-derived Stem Cells Modified with P-selectin Binding Peptide. Advanced Science. 2020, 7(11): 1903516. (*corresponding author)

15.   Meiling Wen, Dengke Zhi, Lina Wang, Ce Cui, Ziqi Huang, Yunhui Zhao, Kai Wang*, Deling Kong, Xiaoyan Yuan*. Local delivery of dual MicroRNAs in trilayered electrospun grafts for vascular regeneration. ACS Applied Materials &Interfaces. 2020, 12(6): 6863-6875. (*corresponding author)

16.   Meifeng Zhu, Wen Li, Xianhao Dong, Xingyu Yuan, Adam C. Midgley, Hong Chang, Yuhao Wang, Haoyu Wang, Kai Wang*, Peter X Ma, Hongjun Wang*, Deling Kong*. In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration. Nature Communications. 2019, 10(1): 4620. (*corresponding author)

17.   Xin Zhou#, Yiwa Pan#, Ruihua Liu, Xin Luo, Xianyan Zeng, Dengke Zhi, Jing Li, Quhan Cheng, Ziqi Huang, Hui Zhang*, Kai Wang*. Biocompatibility and biodegradation properties of polycaprolactone/polydioxanone composite scaffolds prepared by blend or co-electrospinning. Journal of Bioactive and Compatible Polymers. 2019, 34(2): 115-130. (*corresponding author)

18.   Yuna Shang#, Dengke Zhi#, Guowei Feng, Zhongyan Wang, Duo Mao, Shuang Guo, Ruihua Liu, Lulu Liu, Shuhao Zhang, Shenghuan Sun, Kai Wang*, Deling Kong, Jie Gao*, Zhimou Yang*. Supramolecular Nanofibers with Superior Bioactivity to Insulin-Like Growth Factor‐I. Nano Letters. 2019, 19(3): 1560-1569. (*corresponding author)

19.   Qingying Shi, Xin Luo, Ziqi Huang, Adam C. Midgley, Bo Wang, Ruihua Liu, Dengke Zhi,Tingting Wei, Xin Zhou, Mingqiang Qiao, Jun Zhang*, Deling Kong*, Kai Wang*. Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing. Acta Biomaterialia. 2019, 86: 465-479. (*corresponding author)

20.   Muhammad Shafiq, Qiuying Zhang, Dengke Zhi, Kai Wang*, Deling Kong, Dong-Hwee Kim*. In situ blood vessel regeneration using SP (Substance P) and SDF (Stromal cell-derived factor)-1α peptide eluting vascular grafts. Arteriosclerosis Thrombosis, and Vascular Biology. 2018, 38(7): e117-e134. (*corresponding author)

21.   Kang Qin, Yifan Wu, Yiwa Pan, Kai Wang*, Deling Kong, Qiang Zhao*. Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model. Journal of Visualized Experiments. 2018, 136: e57340. (*corresponding author)

22.   Wen Li, Jingrui Chen, Pan Xu, Meifeng Zhu*, Yifan Wu, Zhihong Wang, Tiechan Zhao, Quhan Cheng, Kai Wang*, Guanwei Fan, Yan Zhu, Deling Kong. Long-term evaluation of vascular grafts with circumferentially aligned microfibers in a rat abdominal aorta replacement model. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2018, 106(7): 2596-2604. (*corresponding author)

23.   Yiwa Pan#, Xin Zhou#, Yongzhen Wei, Qiuying Zhang, Ting Wang, Meifeng Zhu, Wen Li, Rui Huang, Ruming Liu, Jingrui Chen, Guanwei Fan, Kai Wang*, Deling Kong, Qiang Zhao*. Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers. Scientific Reports. 2017, 7(1): 3615-3626. (*corresponding author)

24.   Zhihong Wang#, Yifan Wu#, Jianing Wang, Chuangnian Zhang, Hongyu Yan, Meifeng Zhu, Kai Wang*, Chen Li, Qingbo Xu, Deling Kong*. Effect of resveratrol on modulation of endothelial cells and macrophages for rapid vascular regeneration from electrospun poly (ε-caprolactone) scaffolds. ACS Applied Materials &Interfaces. 2017, 9(23): 19541-19551. (*corresponding author)

25.   Kai Wang#, Qiuying Zhang#, Liqiang Zhao, Yiwa Pan, Ting Wang, Dengke Zhi, Shaoyang Ma, Peixin Zhang, Tiechan Zhao, Siming Zhang, Wen Li, Meifeng Zhu, Yan Zhu, Zhang Jun*, Mingqiang Qiao*, Deling Kong*, Functional Modification of Electrospun Poly(ε-caprolactone) Vascular Grafts with the Fusion Protein VEGF-HGFI Enhanced Vascular Regeneration. ACS Applied Materials & Interfaces. 2017, 9(13): 11415-11427. (#co-first author)

26.   Lei Zhu#, Kai Wang#, Teng Ma#, Liangliang Huang#, Bing Xia, Shu Zhu, Yafeng Yang, Zhongyang Liu, Xin Quan, Kai Luo, Deling Kong*, Jinghui Huang*, Zhuojing Luo*, Noncovalent Bonding of RGD and YIGSR to an Electrospun Poly(ε-caprolactone) Conduit through Peptide Self-Assembly to Synergistically Promote Sciatic Nerve Regeneration in Rats. Advanced Healthcare Materials. 2017, 6(8): 1600860. (#co-first author)

27.   Liqiang Zhao#, Shaoyang Ma#, Yiwa Pan, Qiuying Zhang, Kai Wang*, Dongmin Song, Xiangxiang Wang, Guowei Feng, Ruming Liu, Haijin Xu, Jun Zhang, Mingqiang Qiao*, Deling Kong, Functional Modification of Fibrous PCL Scaffolds with Fusion Protein VEGF-HGFI Enhanced Cellularization and Vascularization. Advanced Healthcare Materials. 2016, 5(18): 2376-2385. (*corresponding author)

28.   Kai Wang#, Wenting Zheng#, Yiwa Pan, Shaoyang Ma, Yong Guan, Ruming Liu, Meifeng Zhu, Xin Zhou, Jun Zhang, Qiang Zhao, Yan Zhu*, Lianyong Wang*, Deling Kong, Three-layered PCL Grafts Promoted Vascular Regeneration in a Rabbit Carotid Artery Model. Macromolecular Bioscience. 2016, 16(4): 608-618. (#co-first author)

29.   Huaimin Wang#, Duo Mao#, Youzhi Wang, Kai Wang*, Xiaoyong Yi, Deling Kong, Zhimou Yang, Qian Liu*, Dan Ding*. Biocompatible fluorescent supramolecular nanofibrous hydrogel for long-term cell tracking and tumor imaging applications. Scientific Reports. 2015, 5(1): 1-10. (*corresponding author)

30.   Jun An#, Kai Wang#, Siyuan Chen, Meimei Kong, Yuxin Teng, Lianyong Wang, Cunjiang Song, Deling Kong and Shufang Wang*. Biodegradability, cellular compatibility and cell infiltration of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in comparison with poly(ε-caprolactone) and poly(lactide-co-glycolide). Journal of Bioactive and Compatible Polymers. 2015, 30(2): 209-221.  (#co-first author)

31.   Kai Wang, Xuejiao Chen, Yiwa Pan, Yun Cui, Xin Zhou, Deling Kong, Qiang Zhao*, Enhanced Vascularization in Hybrid PCL/Gelatin Fibrous Scaffolds with Sustained Release of VEGF. Biomed Research International. 2015, 2015: 865076-865086. (first author)

32.   Kai Wang#, Meifeng Zhu#, Ting Li, Wenting Zheng, Li Li, Mian Xu, Qiang Zhao, Deling Kong*, Lianyong Wang*, Improvement of Cell Infiltration in Electrospun Polycaprolactone Scaffolds for the Construction of Vascular Grafts. Journal of Biomedical Nanotechnology. 2014, 10(8): 1588-1598. (#co-first author)

33.   Kai Wang#, Meng Xu#, Meifeng Zhu, Hong Su, Hongjun Wang*, Deling Kong, Lianyong Wang*, Creation of Macropores in Electrospun Silk Fibroin Scaffolds Using Sacrificial PEO-microparticles to Enhance Cellular Infiltration. Journal of Biomedical Materials Research Part A. 2013, 101(12): 3474-3481. (#co-first author)

34.   Kai Wang, Yong Guan, Yi Liu, Meifeng Zhu, Ting Li, Di An, Lailiang Ou*, Yongzhe Che, Guorong Zhang, Jun Zhang*, Xi-Long Zheng, Deling Kong. Fibrin glue with autogenic bone marrow mesenchymal stem cells for urethral injury repair in rabbit model. Tissue Engineering: Part A. 2012, 18(23-24): 2507-2517. (first author)

35.   Min Zhang#, Kai Wang#, Zhexiang Wang, Bin Xing, Qiang Zhao*, Deling Kong*. Small-diameter tissue engineered vascular graft made of electrospun PCL/lecithin blend. Journal of Materials Science - Materials in Medicine. 2012, 23(11): 2639-2648. (#co-first author)