Research Interest：
Mechanisms of bacterial pathogenies and antibiotics resistance
Host immune responses during infection
Education History：
1994-1998， College of Life Sciences, Nankai University，Bachelor of Microbiology
1998-2001，College of Life Sciences, Nankai University，Master of Microbiology
2001-2006， College of Medicine, University of Florida，Doctor of Microbiology
Honors and Awards
Scientific Achievements & Selected Publications
1. Pan X, Liang H, Zhao X, Zhang Q, Chen L, Yue Z, Yin L, Jin Y, Bai F, Cheng Z, Bartlam M, Wu W. Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa. (2023) Nucleic Acids Res. 51(6):2691-2708.
2. Li S, Gong X, Yin L, Pan X, Jin Y, Bai F, Cheng Z, Ha UH, Wu W. Acetylation of CspC Controls the Las Quorum-Sensing System through Translational Regulation of rsaL in Pseudomonas aeruginosa. (2022) mBio. 13(3):e0054722.
3. Gao J, Hu X, Xu C, Guo M, Li S, Yang F, Pan X, Zhou F, Jin Y, Bai F, Cheng Z, Wu Z, Chen S, Huang X, Wu W. Neutrophil-mediated delivery of the combination of colistin and azithromycin for the treatment of bacterial infection. (2022) iScience. 25(9):105035.
4. Pan X, Zhao X, Song Y, Ren H, Tian Z, Liang Q, Jin Y, Bai F, Cheng Z, Feng J, Wu W. Molecular Characterization of WCK 5222 (Cefepime/Zidebactam)-Resistant Mutants Developed from a Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate. (2022) Microbiol Spectr. 10(1):e0267821.
5. Li S, Weng Y, Li X, Yue Z, Chai Z, Zhang X, Gong X, Pan X, Jin Y, Bai F, Cheng Z, Wu W. Acetylation of the CspA family protein CspC controls the type III secretion system through translational regulation of exsA in Pseudomonas aeruginosa. (2021) Nucleic Acids Res. 49(12): 6756–6770.
6. Fan Z, Pan X, Wang D, Chen R, Fu T, Yang B, Jin Y, Bai F, Cheng Z, Wu W. Pseudomonas aeruginosa Polynucleotide Phosphorylase Controls Tolerance to Aminoglycoside Antibiotics by Regulating the MexXY Multidrug Efflux Pump. (2021) Antimicrob Agents Chemother. 65(2):e01846-20.
7. Xia Y, Xu C, Wang D, Weng Y, Jin Y, Bai F, Cheng Z, Kuipers OP, Wu W. YbeY controls the type III and type VI secretion systems and biofilm formation through RetS in Pseudomonas aeruginosa. (2020) Appl Environ Microbiol. AEM.02171-20.
8. Xia Y, Weng Y, Xu C, Wang D, Pan X, Tian Z, Xia B, Li H, Chen R, Liu C, Jin Y, Bai F, Cheng Z, Kuipers OP, Wu W. Endoribonuclease YbeY Is Essential for RNA Processing and Virulence in Pseudomonas aeruginosa. (2020) mBio. 11(3):e00659-20.
9. Pan X, Fan Z, Chen L, Liu C, Bai F, Wei Y, Tian Z, Dong Y, Shi J, Chen H, Jin Y, Cheng Z, Jin S, Lin J, Wu W. PvrA is a novel regulator that contributes to Pseudomonas aeruginosa pathogenesis by controlling bacterial utilization of long chain fatty acids. (2020) Nucleic Acids Res. 48(11):5967-5985.
10. Xia Y, Wang D, Pan X, Xia B, Weng Y, Long Y, Ren H, Zhou J, Jin Y, Bai F, Cheng Z, Jin S, Wu W. TpiA is a Key Metabolic Enzyme That Affects Virulence and Resistance to Aminoglycoside Antibiotics through CrcZ in Pseudomonas aeruginosa. (2020) mBio. 11(1). pii: e02079-19.
11. Tian Z, Cheng S, Xia B, Jin Y, Bai F, Cheng Z, Jin S, Liu X, Wu W. Pseudomonas aeruginosa ExsA regulates a metalloprotease ImpA that inhibits phagocytosis of macrophages. (2019) Infect Immun. Sep 16. pii: IAI.00695-19.
12. Ren H, Liu Y, Zhou J, Long Y, Liu C, Xia B, Shi J, Fan Z, Liang Y, Chen S, Xu J, Wang P, Zhang Y, Zhu G, Liu H, Jin Y, Bai F, Cheng Z, Jin S, Wu W. Combination of Azithromycin and Gentamicin for Efficient Treatment of Pseudomonas aeruginosa Infections. (2019) J Infect Dis. 220(10):1667-1678.
13. Long Y, Fu W, Li S, Ren H, Li M, Liu C, Zhang B, Xia Y, Fan Z, Xu C, Liu J, Jin Y, Bai F, Cheng Z, Liu X, Jin S, Wu W. Identification of novel genes that promote persister formation by repressing transcription and cell division in Pseudomonas aeruginosa. (2019) J Antimicrob Chemother. 74(9):2575-2587.
14. Chen R, Wei X, Li Z, Weng Y, Xia Y, Ren W, Wang X, Jin Y, Bai F, Cheng Z, Jin S, Wu W. Identification of a small RNA that directly controls the translation of the quorum sensing signal synthase gene rhlI in Pseudomonas aeruginosa. (2019) Environ Microbiol. May 20. doi: 10.1111/1462-2920.14686.
15. Xia B, Li M, Tian Z, Chen G, Liu C, Xia Y, Jin Y, Bai F, Cheng Z, Jin S, Wu W. Oligoribonuclease Contributes to Tolerance to Aminoglycoside and β-Lactam Antibiotics by Regulating KatA in Pseudomonas aeruginosa. (2019) Antimicrob Agents Chemother. 63(6). pii: e00212-19.
16. Shi J, Jin Y, Bian T, Li K, Sun Z, Cheng Z, Jin S, Wu W. SuhB is a novel ribosome associated protein that regulates expression of MexXY by modulating ribosome stalling in Pseudomonas aeruginosa. (2015) Mol Microbiol. 98(2): 370-83。
