Doctor degree, professor, State Key Laboratory of Medicinal Chemical Biology , graduated from National Center for Nanoscience and Technology, Chinese Academy of Sciences
National Science Found for Outstanding Young Scholars,
Young and middle-aged leading talents in science and technology innovation under Tianjin Innovative Talents Promotion Plan
China's Top 10 tech Stars in 2020
Research Interest：
Target confirmation of new drugs targeting organelles and lead discovery, including:
1. The regulation and intervention of biomaterials on neuropsychiatric diseases and their molecular mechanisms;
2. Mechanical sensing of neurobiofilms and its intelligent response intervention strategies;
3. Early diagnostic criteria and target screening of neurological diseases.
Education History：
2005.09-2009.07, B.S., Life Science and Technology Base Class, Shenyang Pharmaceutical University
2009.09-2011.07, M.S., Microbiology and Biochemical Pharmacy, Shenyang Pharmaceutical University
2011.09-2014.07, Ph.D, National Center for Nanoscience and Technology, Chinese Academy of Sciences
Honors and Awards
1. The First Prize of Natural Science of Tianjin, 3/8 (2019);
2. Young and middle-aged leading talents in science and technology innovation of Tianjin Innovative Talents Promotion Plan (2020);
3. Top 10 New Talents in Science and Technology (2020);
4. May 4th Medal of Youth of Nankai University (2020);
Scientific Achievements & Selected Publications
Prof. Xue has published Nature Nanotechnology, Molecular Cell, Nature Communications, Science Advances et al. as first author or corresponding author, and her papers were cited by more than 900 times. At the same period, she published an English book as editor in Springer Nature (Singapore), 2019.
Ten representative publication:
1. Wang HP, Chen X, Qi YL, Wang CX, Huang LW, Wang R, Li JM, Xu XH, Zhou YT, Liu Y, Xue X*. Self-propelled Nanomotors with Alloyed Engine for Emergency Rescue of Traumatic Brain Injury. Advanced Materials, 2022, 34(49):2206779.
2. Huang LW#, Zhang X#, Ding ZW, Qi YL, Wang WJ, Xu XH, Yue H, Bai LH, Wang HP, Feng LY, Ren J, Yang X, Ma GH*, Wei W*, Xue X*. PEGylated 2D-nanomaterials Alleviate Parkinson's Disease by Shielding PIP2 Lipids to Inhibit IP3 Second Messenger Signaling. Nano Today, 2022, 46:101556.
3. Wang HP, Chen X, Qi YL, Huang LW, Wang CX, Ding D, Xue X*. Aggregation-Induced Emission (AIE)-guided Dynamic Assembly for Disease Imaging and Therapy. Advanced Drug Delivery Reviews, 2021, 179:114028.
4. Yang JY#, Wang LR#, Huang LW, Che XH, Zhang Z, Wang CX, Bai LH, Liu P, Zhao YN, Hu XM, Shi BY, Shen YQ, Liang XJ, Wu CF*, Xue X*. Receptor-targeting Nanomaterials Alleviate Binge Drinking-induced Neurodegeneration as Artificial Neurotrophins. Exploration, 2021, 1:61-74.
5. Qi J#, Feng LY#, Zhang XY, Zhang HK, Huang LW, Zhou YT, Zhao Z, Duan XC, Xu F, Kwok RK., Lam JY, Ding D, Xue X*, Tang BZ*. Facilitation of Molecular Motion to Develop Turn-on Photoacoustic Bioprobe for Detecting Nitric Oxide in Encephalitis. Nature Communications, 2021, 12(1):960.
6. Zhou YT#, Zhu FY#, Liu Y#, Zheng M, Wang YB, Zhang DY, Anraku Y, Zou Y, Li J, Wu HG, Pang XB, Tao W, Shimoni O, Bush A. I, Xue X*, Shi BY*. Blood-brain Barrier-penetrating siRNA Nanomedicine for Alzheimer’s Disease Therapy. Science Advances, 2021, 6(41), eabc7031.
7. Xue X#, Yang JY#, He Y#, Wang LR, Liu P, Yu LS, Bi GH, Zhu MM, Liu YY, Xiang RW, Yang XT, Fan XY, Wang XM, Qi J, Zhang HJ, Wei T, Cui W, Ge GL, Xi ZX*, Wu CF*, Liang XJ*. Aggregated Single-Walled Carbon Nanotubes Attenuate the Behavioural and Neurochemical Effects of Methamphetamine in Mice. Nature Nanotechnology, 2016, 11(7): 613-620.
8. Wang Z#, Miao GY#, Xue X#, Guo XY, Yuan CZ, Wang ZY, Zhang GM, Chen YY, Feng D, Hu JJ, Zhang H*. The Vici Syndrome Protein EPG5 is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes. Molecular Cell, 2016, 63(5):781-795.
9. Xue X, Wang LR, Sato Y, Jiang Y, Berg M, Yang DS, Nixon RA*, Liang XJ*. Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease. Nano Letters, 2014, 14(9): 5110-5117.
10. Xue X, Hall MD, Zhang Q, Wang PC, Gottesman MM*, Liang XJ*. Nanoscale Drug Delivery Platforms Overcome Platinum-Based Resistance in Cancer Cells Due to Abnormal Membrane Protein Trafficking. ACS Nano, 2013, 7(12):10452-10464.
Representative monograph:
Xue X (Editor) Nanomedicine in Brain Diseases: Principles and Application. Springer Nature (Singapore), ISBN 978-981-13-8730-2, ISBN 978-981-13-8731-9 (eBook), https://doi.org/10.1007/978-981-13-8731-9. December 23, 2019
