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杨雪 研究员 Xue Yang
Ph.D., Professor, State laboratory of Chemical Medical Biology
Special Talent：
Address： State Key Laboratory of Medicinal Chemical Biology, Laboratory building D214, Nankai University, (Jinnan Campus), Tianjin, China
Telephone： 86-22-85358251
Email： yangxue(AT)nankai.edu.cn
Research Group Website：

Research Interest：

Our laboratory is focused on elucidating the molecular mechanisms that underlie transmembrane signal transduction. Our long-term research goal is to investigate the structural and functional aspects of the receptors and channels involved in transmembrane signal transduction. To achieve this objective, we employ an integrative approach, harnessing state-of-the-art methodologies including cryo-electron microscopy (cryo-EM), biochemical analyses, fluorescence microscopy imaging, and electrophysiology techniques. Our work is poised to provide pivotal insights for advancing drug discovery and enhancing the therapeutic strategies for diseases associated with these signaling pathways.

Education History：

China Agricultural University, Beijing, P.R. China

B.S.A. Agronomy, 2006

Nankai University, Tianjin, P.R. China

Ph.D. Biochemistry and Molecular Biology, 2012

Honors and Awards

Scientific Achievements & Selected Publications

M. Li, Y. Li, Y. Lu, J. Li, X. Lu, Y. Ren, T. Wen, Y. Wang, S. Chang, X. Zhang, X. Yang*, Y. Shen*. Molecular basis of Mg2+ permeation through the human mitochondrial Mrs2 channel, Nature Communications, 2023 Aug 5; 14(1):4713

Y. Ren, Y. Li, Y. Wang, T. Wen, X. Lu, S. Chang, X. Zhang, Y. Shen*, X. Yang*, Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel, Journal of Biological Chemistry. 2022 Mar 23;101838..

X. Chen, Y. Wang, Y. Li, X. Lu, J. Chen, M. Li, T. Wen, N. Liu, S. Chang, X. Zhang, X. Yang*, Y. Shen*, Cryo-EM structure of the human TACAN in a closed state, Cell Reports. 2022 Mar 1;38(9):110445.

T. Wen, Z. Wang, X. Chen, Y. Ren, X. Lu, Y. Xing, J. Lu, S. Chang, X. Zhang, Y. Shen*, X. Yang*, Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor, Science Advances. 2021 Jun;7(23):eabg1483.

Y. Ren, T. Wen, Z. Xi, S. Li, J. Lu, X. Zhang, X. Yang*, Y. Shen*, Cryo-EM structure of the calcium homeostasis modulator 1 channel, Science Advances. 2020 Jul;6(29):eaba8161.

X. Liu, G. Wu, Y. Yu, X. Chen, R. Ji, J. Lu, X. Li, X. Zhang, X. Yang*, Y. Shen*, Molecular understanding of calcium permeation through the open Orai channel, PLoS Biology. 2019 Apr;17(4):e3000096.

Y. Xing, M. Wang, J. Wang, Z. Nie, G. Wu, X. Yang*, Y. Shen*, Dimerization of MICU Proteins Controls Ca(2+) Influx through the Mitochondrial Ca(2+) Uniporter, Cell Reports. 2019 Jan 29;26(5):1203-1212 e1204.

X. Li, G. Wu, Y. Yang, S. Fu, X. Liu, H. Kang, X. Yang*, X.C. Su*, Y. Shen*, Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers, Nature Communications. 2017 Oct 19;8(1):1042.

L. Wang, X. Yang (co-first), S. Li, Z. Wang, Y. Liu, J. Feng, Y. Zhu, Y. Shen*, Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake, EMBO Journal. 2014 Mar 18;33(6):594-604.

X. Yang, H. Jin, X. Cai, S. Li, Y. Shen*, Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1), Proceedings of the National Academy of Sciences of the United States of America. 2012 Apr 10;109(15):5657-5662.

Q. Yan, Y. Shen, X. Yang*, Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7, Journal of Structural Biology 2022 Mar;214(1):107832.

Y. Lu, X. Lu, Y. Xu, Y. Ren, Y. Shen, X. Yang*, Expression, purification and microscopic characterization of transmembrane BAX Inhibitor-1 motif containing protein 5, Protein Expression and Purification. 2022 May;193(106045.

S. Li, Y. Ren, X. Lu, Y. Shen, X. Yang*, Cryo-EM structure of human ABCB8 transporter in nucleotide binding state, Biochemistry and Biophysical Research Communications. 2021 Jun 11; 557, 187-191.

Z. Nie, Q. Yan, Y. Shen, X. Yang*, Expression, purification and microscopic characterization of human ATP-binding cassette sub-family B member 7 protein, Protein Expression and Purification. 2021 Jul; 183, 105860.

Y. Zhang, Y. Li, X. Liu, J. Sun, X. Li, J. Lin, X. Yang*, Z. Xi*, Y. Shen*, Molecular architecture of the acetohydroxyacid synthase holoenzyme, Biochemical Journal 2020 Jul 17; 477(13), 2439-2449.

X. Yang, D.L. Clemens, B.Y. Lee, Y. Cui, Z.H. Zhou*, M.A. Horwitz*, Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique alpha-Helical Lid and a Putative Cargo, Structure. 2019 Dec 3;27(12):1811-1819 e1816.

G. Wu, S. Li, G. Zong, X. Liu, S. Fei, L. Shen, X. Guan, X. Yang*, Y. Shen*, Single channel recording of a mitochondrial calcium uniporter, Biochemistry and Biophysical Research Communications. 2018 Jan 29;496(1):127-132.

J. Feng, S. Fu, X. Cao, H. Wu, J. Lu, M. Zeng, L. Liu, X. Yang*, Y. Shen*, Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex, Protein & Cell. 2017 Jul;8(7):538-543.

S. Fu, L. Li, H. Kang, X. Yang*, S. Men*, Y. Shen*, Chronic mitochondrial calcium elevation suppresses leaf senescence, Biochemistry and Biophysical Research Communications. 2017 Jun 3;487(3):672-677.

J. Shao, Z. Fu, Y. Ji, X. Guan, S. Guo, Z. Ding, X. Yang*, Y. Cong*, Y. Shen*, Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca(2+)/H(+) antiporter, Scientific Reports. 2016 Sep 27;6(34174.

L. Li, Y. Xing, D. Chang, S. Fang, B. Cui, Q. Li, X. Wang, S. Guo, X. Yang*, S. Men*, Y. Shen*, CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence, Scientific Reports. 2016 Aug 19;6(31889.

B. Cui, S. Fang, Y. Xing, Y. Shen*, X. Yang*, Crystallographic analysis of the Arabidopsis thaliana BAG5-calmodulin protein complex, Acta Crystallographica Section F: Structural Biology Communications. 2015 Jul;71(Pt 7):870-875.

Z. Wang, X. Yang, X. Chu, J. Zhang, H. Zhou, Y. Shen*, J. Long*, The structural basis for the oligomerization of the N-terminal domain of SATB1, Nucleic Acids Research. 2012 May;40(9):4193-4202.

Z. Wang, X. Yang, S. Guo, Y. Yang, X.C. Su, Y. Shen*, J. Long*, Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism, Journal of Biological Chemistry. 2014 Oct 3;289(40):27376-27385.

B. Cui, X. Yang, S. Li, Z. Lin, Z. Wang, C. Dong, Y. Shen*, The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1, PLoS One. 2013 8(9):e74735.

S. Fang, L. Li, B. Cui, S. Men, Y*. Shen*, X. Yang*, Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana, Acta Crystallographica Section D: Structural Biology. 2013 Jun;69(Pt 6):934-945.

C. Dong, X. Yang, H.F. Hou, Y.Q. Shen*, Y.H. Dong*, Structure of Escherichia coli BamB and its interaction with POTRA domains of BamA, Acta Crystallographica Section D: Structural Biology. 2012 Sep;68(Pt 9):1134-1139.

J. Zhang, X. Yang*, Y. Shen, J. Long, Crystallization and preliminary X-ray data collection of the L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) tripartite complex, Acta Crystallographica Section F: Structural Biology Communications. 2011 Nov 1;67(Pt 11):1443-1447.

X. Yang, X. Xie, L. Chen, H. Zhou, Z. Wang, W. Zhao, R. Tian, R. Zhang, C. Tian*, J. Long, Y*. Shen*, Structural basis for tandem L27 domain-mediated polymerization, FASEB Journal. 2010 Dec;24(12):4806-4815.

X. Yang, Z. Wu, X. Wang, C. Yang, H. Xu, Y. Shen*, Crystal structure of lipoprotein GNA1946 from Neisseria meningitidis, Journal of Structural Biology. 2009 Dec;168(3):437-443.