Research Interest：
Nucleic Acids research, Telomere biology, Epigenetics, Single-molecule instrumentation
Education History：
1996-2001，Tongji Medical College, Huazhong University of Science and Technology，Bachelor of Medicine
2004-2007，Institute of Health, Zhejiang Academy of Medical Sciences，Master of Medicine
2008-201，Department of Chemistry, Kent State University，Doctor of Chemistry
Scientific Achievements & Selected Publications
1. Wang Z, Cao Z, Ma K, Lu M, Wang M, Gao H, Gong D, Liang L, Yu Z. Reading Time and DNA Sequence Preference of TET3 CXXC Domain Revealed by Single-Molecule Profiling. Chin. J. Chem. 2023, 41, 1177-1184.
2. Liang L, Ma K, Wang Z, Janissen R, Yu Z. Dynamics and Inhibition of MLL1 CXXC Domain on DNA Revealed by Single-Molecule Quantification. Biophys J. 2021 Aug 17; 120(16):3283-3291.
3. Liang L, Wang Z, Qu L, Huang W, Guo S, Guan X, Zhang W, Sun F, Yuan H, Zou H, Liu H, Yu Z. Single-molecule multiplexed profiling of protein-DNA complexes using Magnetic Tweezers. J Biol Chem. 2021 Jan-Jun; 296:100327.
4. Li X, Wang M, Zheng W, Huang W, Wang Z, Jin K, Liu L, Yu Z. Dynamics of TRF1 organizing a single human telomere. Nucleic Acids Res. 2021 Jan 25; 49(2):760-775.
5. Ma X, Zhu M, Liu J, Li X, Qu L, Liang L, Huang W, Wang J, Li N, Chen JH, Zhang W, Yu Z. Interactions between PHD3-Bromo of MLL1 and H3K4me3 Revealed by Single-Molecule Magnetic Tweezers in a Parallel DNA Circuit. Bioconjug Chem. 2019 Dec 18; 30(12):2998-3006.
6. Li N, Wang J, Ma K, Liang L, Mi L, Huang W, Ma X, Wang Z, Zheng W, Xu L, Chen JH, Yu Z. The dynamics of forming a triplex in an artificial telomere inferred by DNA mechanics. Nucleic Acids Res. 2019 Sep 5;47(15):e86.
7. Yu Z, Cui Y, Selvam S, Ghimire C, Mao H. Dissecting cooperative communications in a protein with a high-throughput single-molecule scalpel. Chemphyschem. 2015;16(1):223-232.
8. Yu Z, Dulin D, Cnossen J, Köber M, van Oene MM, Ordu O, Berghuis BA, Hensgens T, Lipfert J, Dekker NH. A force calibration standard for magnetic tweezers. Rev Sci Instrum. 2014;85(12):123114.
