Research Interest：
1.Development of antibody based tumor immunotherapy, the mechanistic study of drug resistance and design of combination therapies that can increase the proportion of responsive patients.
2.Development of oncolytic virus based on the concept of artificial APC, mechanistic study of drug resistance, design of next generation of OV and combination therapy.
3.Development of bispecific antibody for infectious disease based on the principle of immunology.
Education：
2004/9-2009/7，College of Life Science, Nankai University, PhD of Biochemistry and molecular biology
2000/9-2004/7，College of Life Science, Nankai University, Bachelor of Biology
Honors and Awards：
Scientific Achievements & Selected Publications：
1.Yuan Wang#, Ruina Jin#, Bingqing Shen, Na Li, He Zhou, Wei Wang, Yingjie Zhao, Mengshi Huang, Pan Fang, Shanshan Wang, Pascaline Mary, Ruikun Wang, Peixiang Ma, Ruonan Li, Yujie Tian, Youjia Cao, Fubin Li, Liang Schweizer, Hongkai Zhang*, High-throughput functional screening for next-generation cancer immunotherapy using droplet-based microfluidics, Science Advances,2021, 7(24):eabe3839.
2.Kai Ye, Fan Li, Ruikun Wang, Tianyi Cen, Shiyu Liu, Zhuoqian Zhao,Ruonan Li, Lili Xu, Guanmeng Zhang, Zhaoyuan Xu, Li Deng,Lili Li,Wei Wang, Alexey Stepanov, Yajuan Wan,Yu Guo, Yuanke Li,Yuan Wang,Yujie Tian, Alexander G. Gabibov, Yingbin Yan*, Hongkai Zhang*, An armed oncolytic virus enhances the efficacy of tumor-infiltrating lymphocyte therapy by converting tumors to artificial antigen-presenting cells in situ, Molecular Therapy, 2022, 30(12):3658-3676.
3. Yuexia Liang#, Xin Li#, Fengping Peng, Xiaohan Ye,Wei Wang, Tianyi Cen, Fan Li,Yue Lu, Zhaoyun Liu, Hui Liu, Kai Ding, Kai Ye, Yang Yu, Tianyu Ma, Sihe Zhang, Yi Huang, Yuan Wang, Xue Yang, Rong Fu*, Hongkai Zhang*, Self-assembly of X-shaped antibody to combine the activity of IgG and IgA for enhanced tumor killing. Theranostics, 2022.12(18):7729-7744.
