Research Interest：
Focusing on the key scientific issues of "how to promote tissue damage repair and regeneration", the applicant has carried out a series of basic and clinical transformation research related to the improvement of tissue repair with biomaterials by using new engineering technologies and methods. The construction of artificial blood vessels with guiding structure solves the bottleneck problem of "pseudo natural regeneration of blood vessels in vivo". A new method was established and developed to accurately control the topological pore structure of extracellular matrix materials and effectively promote the in situ regeneration of oriented tissues. An in situ antibacterial hemostatic and regenerative multichannel sponge material was developed. Neural catheter products are undergoing clinical transformation.
Education History：
2000.09-2004.07,College of Life Sciences, Northwest Agriculture and Forestry University，Bachelor of Biotechnology
2009.09-2012.07,College of Life Sciences, Nankai University，Master of Biochemistry and Molecular Biology
2012.09-2015.07,College of Life Sciences, Nankai University，Doctor of Biochemistry and Molecular Biology
Honors and Awards
1. First prize of Tianjin Intellectual Property Innovation, Entrepreneurship, Invention and Design Competition , 2021
2. Gold Award of the 5th China "Internet Plus" College Student Innovation and Entrepreneurship Competition ,2019
Scientific Achievements & Selected Publications
1. Liu S, Yao L, Wang Y, Li Y, Jia Y, Yang Y, Na Li, Hu Y, Kong D, Dong X*, Wang K*, Zhu M*, Immunomodulatory hybrid micro-nanofiber scaffolds enhance vascular regeneration, Bioactive Materials, 2023, 21, 464-482. （IF：16.874）
2. He X, Li W, Liu S, Li Y, Chen Y, Dan N, Dan W*, Zhu M*. Fabrication of high-strength, flexible, porous collagen-based scaffolds to promote tissue regeneration. Mater Today Bio. 2022 Aug 5;16:100376. doi: 10.1016/j.mtbio.2022.100376. （IF：10.761）
3. Du X, Wu L,Yan H, Jiang Z, Li S, Li W, Bai Y, Wang H, Cheng Z, Kong D*, Wang L*, Zhu M*. Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing. Nature communications, 2021, 12: 4733. （IF：17.694）
4. Zhu M, Li W, Dong X, Yuan X, Midgley A, Chang H, Wang Y, Wang H, Wang K*, Ma PX, Wang H*, Kong D*. In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration. Nature communications, 2019, 10(1): 1-14.（IF：17.694）
5. Zhi D, Cheng Q, Midgley AC, Zhang Q, Wei T, Li Yi, Wang T, Ma T, Rafique M, Xia S, Cao Y, Li Y, Li J, Che Y, Zhu M*, Wang K*, Kong D* Mechanically reinforced biotubes for arterial replacement and arteriovenous grafting inspired by architectural engineering. Science Advances, 2022 8, eabl3888.（IF：14.957）
6. Wang H, Zhou X, Wang J, Zhang X, Zhu M*, Wang H*, Fabrication of channeled scaffolds through polyelectrolyte complex (PEC) printed sacrificial templates for tissue formation, Bioactive Materials, 2022, 17: 261-275.（IF：16.874）
7. Dong X, Liu S, Yang Y, Gao S, Li W, Cao J, Wan Y, Huang Z, Fan G, Chen Q, Wang H*, Zhu M*, Kong D*. Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration. Biomaterials, 2021, 272: 120767. （IF：15.304）
8. Li W, Bai Y, Cao J, Gao S, Xu P, Feng G, Wang L, Wang H, Kong D, Fan M*, Zhang J*, Zhu M*. Highly interconnected inverse opal extracellular matrix scaffolds enhance stem cell therapy in limb ischemia. Acta Biomaterialia, 2021, 128: 209-221.（IF：10.633）
9. Yan H, Mi X, A Midgley, Du X, Huang Z, Wei T, Liu R, Ma T, Zhi D, Zhu M*, Kong D*, Wang K*. Targeted Repair of Vascular Injury by Adipose-derived Stem Cells Modified with P-selectin Binding Peptide. Advanced Science, 2020, 7: 1903516. IF：17.521）
10. Wu P, Wang L, Li W, Zhang Y, Wu Y, Zhi D, Wang H, Wang L*, Kong D*, Zhu M*. Construction of vascular graft with circumferentially oriented microchannels for improving artery regeneration. Biomaterials, 2020, 119922. （IF：15.304）
11. Li W, Midgley A, Bai Y, Zhu M*, Chang H, Zhu W, Wang L, Wang Y, Wang H, Kong D*. Subcutaneously engineered autologous extracellular matrix scaffolds with aligned microchannels for enhanced tendon regeneration. Biomaterials, 2019, 224:119488.（IF：15.304）
12. Zhu M1, Wu Y1, Li W, Dong X, Chang H, Wang K, Wu P, Zhang J, Fan G, Wang L, Liu J, Wang H*, Kong D*. Biodegradable and elastomeric vascular grafts enable vascular remodeling. Biomaterials, 2018, 183: 306-318.（IF：15.304）
13. Dong X, Yuan X, Wang L, Liu J, Midgley AC, Wang Z, Wang K, Liu J, Zhu M*, Kong D*. Construction of a bilayered vascular graft with smooth internal surface for improved hemocompatibility and endothelial cell monolayer formation. Biomaterials, 2018, 181: 1-14. （IF：15.304）
14. Zhu M1, Wang Z1, Zhang J, Wang L, Yang X, Chen J, Fan G, Ji S, Xing C, Wang K, Zhao Q, Zhu Y, Kong D*, Wang L*. Circumferentially aligned fibers guided functional neoartery regeneration in vivo, Biomaterials, 2015, 61: 85-94.（IF：15.304）
15. Li L, Wang Y, Guo R, Li S, Ni J, Gao S, Gao X, Mao J, Zhu Y, Wu P, Wang H, Kong D, Zhang H*, Zhu M*, Fan G*. Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury. Journal of Controlled Release. 2020, 317: 259-272. （IF：11.467）
16. Zhu M, Wang K, Mei J, Li C, Zhang J, Zheng W, An D, Xiao N, Zhao Q, Kong D*, Wang L*. Fabrication of highly interconnected porous silk fibroin scaffolds for potential use as vascular grafts, Acta Biomaterialia, 2014, 10: 2014-2023.（IF：10.633）
17. Gao S，Wang L，Zhang Y，Li L，Zhang Y，Gao X，Mao J，Wang L*，Wang L，Wang H，Zhu M*，Fan G*. Tanshinone IIA-loaded aligned microfibers facilitate stem cell recruitment and capillary formation by inducing M2 macrophage polarization[J]. Applied Materials Today, 2020, 21: 100841. （IF：8.633）
18. Jiang Z, Zhang K, Du L*, Cheng Z, Zhang T, Ding J, Li W, Xu B*, Zhu M*. Construction of chitosan scaffolds with controllable microchannel for tissue engineering and regenerative medicine. Mater Sci Eng C Mater Biol Appl, 2021, 126: 112178. （IF：8.457）
19. Yuan X, Li W, Yao B, Li Z, Kong D, Huang S*, Zhu M*. Tri-Layered Vascular Grafts Guide Vascular Cells' Native-like Arrangement. Polymers (Basel). 2022 Mar 28;14(7):1370. doi: 10.3390/polym14071370. PMID: 35406244; PMCID: PMC9003212. （IF：4.967）
20. Mao D1, Zhu M1, Zhang X, Ma R, Yang X, Ke T, Wang L, Li Z*, Kong D, Li C*. A macroporous heparin-releasing silk fibroin scaffold improves islet transplantation outcome by promoting islet revascularisation and survival, Acta Biomaterialia. 2017, 59: 210-220. （IF：10.633）
21. Ding X1, Zhu M1, Xu B, Zhang J, Zhao Y, Ji S, Wang L, Wang L*, Li X, Kong D, Ma X, Yang Q*, Integrated Trilayered Silk Fibroin Scaffold for Osteochondral Differentiation of Adipose-Derived Stem Cells, ACS Appl. Mater. Interfaces, 2014, 6: 16696-705. （IF：10.383）
22. Li L, Ni J, Li M, Chen J, Han L, Zhu Y, Kong D, Mao J, Wang Y, Zhang B, Zhu M*, Gao X*, Fan G*. Ginsenoside Rg3 micelles mitigate doxorubicin-induced cardiotoxicity and enhance its anticancer efficacy, Drug Delivery, 2017, 24: 1617-1630. （IF：6.819）
23. Du L, Li W, Jiang Z, Wang L, Kong D, Xu B*, Zhu M*. Hierarchical macro/micro-porous silk fibroin scaffolds for tissue engineering. Materials Letters, 2019, 236: 1-4. （IF：3.574）
24. Li W, Chen J, Xu P, Zhu M*, Wu Y, Wang Z, Zhao T, Cheng Q, Wang K*, Fan G, Zhu Y, Kong D. Long‐term evaluation of vascular grafts with circumferentially aligned microfibers in a rat abdominal aorta replacement model. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2018, 106(7): 2596-2604. （IF：3.405）
25. Li W, Wu P, Zhang Y , Midgley A, Yuan X, Wu Y, Wang L, Wang Z *, Zhu M*, Kong D. Bi-layered polymeric micro- and nano-fiber vascular grafts as abdominal aorta replacements: Long-term in vivo studies in a rat model. ACS Applied Bio Materials, https://doi.org/10.1021/acsabm.9b00641.
26. Wang K1, Zhu M1, Li T, Zheng W, Li L, Xu M, Zhao Q, Kong D, Wang L. Improvement of Cell Infiltration in Electrospun Polycaprolactone Scaffolds for the Construction of Vascular Grafts, Journal of Biomedical Nanotechnology, 2014, 10: 1588-1598. （IF：3.641,）
27. Du L1, Zhu M1, Yang Q, Zhang J, Ma X, Kong D, Li X, Xu B, Wang L*. A novel 3D biphasic silk composite scaffold for intervertebral disc tissue engineering. Materials letters, 2014, 117: 237-240. （IF：3.574）
28. Zhang J, Wang L, Zhu M, Wang L, Kong D. Wet-spun poly（ε-caprolactone） microfiber scaffolds for oriented growth and infiltration of smooth muscle cells. Materials letters, 2014, 132: 59-62. （IF：3.574）
29. Du L, Yang Q, Zhang J, Zhu M, Ma X, Zhang Y, Wang L, Xu B. Engineering a biomimetic integrated scaffold for intervertebral disc replacement. Materials Science and Engineering: C, 2019, 96: 522-529. （IF：8.457）
30. Gao S, Wang Y, Li D, Guo Y, Zhu M, Xu S, Mao J, Fan G. TanshinoneIIA Alleviates Inflammatory Response and Directs Macrophage Polarization in Lipopolysaccharide-Stimulated RAW264. 7 Cells. Inflammation, 2019, 42: 264-275. （IF：4.657）
31. Zeng C, Yang Q, Zhu M, Zhang J, Li X, Xu B, Wang L. Silk Fibroin Porous Scaffolds for Nucleus Pulposus Tissue Engineering, Materials Science and Engineering C, 2014, 37: 232-240.（IF：8.457）
32. Mei J, Zhang X, Zhu M, Wang J, Wang L, Wang L. Barium-triggered β-sheet formation and hydrogelation of a short peptide derivative, RSC Advances. 2014, 4: 1193-1196.（IF：4.036）
33. Wang K, Xu M, Zhu M, Su H, Wang H, Kong D, Wang L. Creation of macropores in electrospun silk fibroin scaffolds using sacrificial PEO-microparticles to enhance cellular infiltration, J Biomed Mater Res Part A , 2013 101: 3474-3481. （IF：4.854）
34. Wei J, Wang H, Zhu M, Ding D, Li D, Yin Z, Wang L, Yang Z. Janus nanogels of PEGylated Taxol and PLGA–PEG–PLGA copolymer for cancer therapy, Nanoscale, 2013, 5: 9902-990.（IF：8.307）
35. Wang K, Guan Y, Liu Y, Zhu M, Li T, An D, Ou L, Che Y, Zhang G, Zhang J, Zheng X, Kong D. Fibrin glue with autogenic bone marrow mesenchymal stem cells for urethral injury repair in rabbit model.Tissue Eng Part A. 2012,18: 2507-17.（IF：4.080）
36. Wang K，Zheng W，Pan Y，Ma S，Guan Y, Liu R，Zhu M，Zhou X，Zhang J，Zhao Q，Zhu Y，Wang L, Kong D，Three-layered PCL Grafts Promoted Vascular Regeneration in a Rabbit Carotid Artery Model. Macromolecular Bioscience. 2016. 2016, 16: 608-618（IF：5.859）
37. Ke T, Yang M, Mao D, Zhu M, Che Y, Kong D, Li C. Co-Transplantation of Skin-Derived Precursors and Collagen Sponge Facilitates Diabetic Wound Healing by Promoting Local Vascular Regeneration. Cell Physiol Biochem. 2015; 37:1725-37.
38. Pan Y, Zhou X, Wei Y, Zhang Q, Wang T, Zhu M, Li W, Huang R, Liu R, Chen J, Fan G, Wang K, Kong D, Zhao Q. Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers. Sci Rep, 2017, 7: 3615. （IF：4.996）
39. Wang Z, Wu Y, Wang J, Zhang C, Yan H, Zhu M, Wang K, Li C, Xu Q, Kong D. Effect of Resveratrol on Modulation of Endothelial Cells and Macrophages for Rapid Vascular Regeneration from Electrospun Poly(ε-caprolactone) Scaffolds. ACS Appl Mater Interfaces, 2017, 9: 19541-19551.（IF：10.383）
40. Wang K, Zhang Q, Zhao L, Pan Y, Wang T, Zhi D, Ma S, Zhang P, Zhao T, Zhang S, Li W, Zhu M, Zhu Y, Zhang J, Qiao M, Kong D. Functional Modification of Electrospun Poly(ε-caprolactone) Vascular Grafts with the Fusion Protein VEGF-HGFI Enhanced Vascular Regeneration. ACS Appl Mater Interfaces, 2017, 9: 11415-11427. （IF：10.383）
