Doctor degree, associated professor, State laboratory of Chemical Medical Biology, graduated from Nankai University
National Science Found for Distinguished Young Scholars/ National Science Found for Outstanding Young Scholars/Peer level Young Scholar
Research Interest：
Mitochondria are the “power house” and “powder house” of the cell, controlling a variety of pivotal cellular processes such as metabolism, cell death, innate immunity, etc. The duality of mitochondria, Yin and Yang, highlights the importance of mitochondrial homeostasis for the cell function. We focus on the mechanisms of maintaining mitochondrial homeostasis, such as mitophagy, mitochondrial dynamics, and mitochondrial biogenesis. We are also interested in developing new mitochondria-based strategies to screen compounds, aiming to delay aging and cure mitochondrial diseases.
Education History：
2005-2009，College of Life Sciences, Nankai University，Bachelor of Biology
2009-2014，College of Life Sciences, Nankai University，Doctor of Cell Biology
Honors and Awards
Scientific Achievements & Selected Publications
1. Chen G, et al, Kepp O*, Kroemer G*, 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Molecular Medicine, 2019;11:e10469.
2. Sauvat A#, Chen G#, et al, Kepp O*, Kroemer G*, Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. EBioMedicine, 2018; 30: 261–272.
3. Chen G#, Han Z#, et al, Zhu Y*, Chen Q*, A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Molecular cell, 2014;54(3): 362-77.
4. Liu L#, Du F#, Chen G#, et al, Chen Q*, Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nature cell biology, 2012;14:177-185.
5. Chen G, Kroemer G, Kepp O. Mitophagy: An Emerging Role in Aging and Age-Associated Diseases. Frontiers in Cell and Developmental Biology, 2020; 8:200.
