Research Interest：
1. Construction of high-performance biocatalysts based on the accurate assemble/immobilization using porous materials;
2. Formulation of biomacromolecules for enzyme preparation and bioagents development;
3. Development of high-performance separation media
4. Design of porous framework materials for bio-applications, such as funcional carriers for enzyme-immobilization.
Biographical Sketch:
Yao Chen is a professor and doctoral supervisor of State Key Laboratory of Medicinal Chemical Biology and School of Pharmacy in Nankai University, China. She received the master's degree from Nanjing University of technology in 2009, and then the doctor's degree from the University of South Florida in 2014, and engaged in postdoctoral research at the University of California, San Diego from 2014 to 2016. She joined Nankai University in July 2016 and established independent research group that focuses on the precise immobilization and functional formulation of biomacromolecules. She has published 100 SCI papers. As the corresponding/first author she has published 56 papers including Nat Commun、Nat Protoc、Nat Rev Chem, JACS, Angew Chem Int Ed, Adv Mater, Chem, Sci Adv、ACS Catal, Chem Soc Rev. 10 papers have been selected as ESI highly-cited paper. She has 37 authorized/applied Chinese patents and 3 U.S. patents. She is the member of the council of The Chemical Industry and Engineering Society of China (CIESC).
Honors and Awards
• Distinguished Researcher in Tianjin 2022
• Won the silver Prize in the 7th China International College Students’’Internet +’ Innovation and Entrepreneurship Competition.
• Chinese Government Award for Outstanding Self-financed Students Abroad of Year 2013
• Barbara B. Martin Endowed Fellowship in Chemistry, University of South Florida，2012
Scientific Achievements & Selected Publications（from 2017）
1. Qianqian Zhu, Yunlong Zhao, Zhenjie Zhang*, Yao Chen*, Enzyme Immobilization on Covalent Organic Framework Supports, Nature Protocols, 2023, in press.
2. Yifan Feng+, Ruixuan Shi+, Mingfang Yang+, Yunlong Zheng, Zhenjie Zhang and Yao Chen*, A Dynamic Defect Generation Strategy for Efficient Enzyme Immobilization in Robust Metal-Organic Frameworks for Catalytic Hydrolysis and Chiral Resolution. Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202302436.
3. Jinxia Wei, Rui Li, Penghui Zhang, Haiqun Jin, Zhenjie Zhang, Yubo Li*, Yao Chen*, Efficient and Selective Removal of Uremic Toxin Precursor by Olefin-linked COFs for Nephropathy Treatment, Nat. Commun. 2023, in press
4. Zhifang Wang, Qianqian Zhu, Jiaxi Wang, Fazheng Jin, Penghui Zhang, Dong Yan, Peng Cheng, Yao Chen*, Zhenjie Zhang*, Industry-compatible covalent organic frameworks for green chemical engineering. Sci. China Chem, 2022, 65.
5. Yunlong Zheng, Sainan Zhang, Jinbiao Guo, Ruixuan Shi, Jiangyue Yu, Kaipeng Li, NingLi, ZhenjieZhang, and Yao Chen*, Green and Scalable Fabrication of High-Performance Biocatalysts Using Covalent Organic Frameworks as Enzyme Carriers, Angew. Chem. Int. Ed. 2022, e202208744.
6. Zhengfeng Zhao+, Dong Zheng+, Menglei Guo, Jiangyue Yu, Sainan Zhang, Zhenjie Zhang,and Yao Chen*, Engineering Olefin-Linked Covalent Organic Frameworks for Photoenzymatic Reduction of CO2, Angew. Chem. Int. Ed. 2022, 61, e202200261.
7. Zhengfeng Zhao,* Xuepeng Chen, BaoYing Li, Shu Zhao, Liwei Niu,* Zhenjie Zhang, and Yao Chen*, Spatial Regulation of Acceptor Units in Olefin-Linked COFs toward Highly Efficient Photocatalytic H2 Evolution, Adv. Sci. 2022, 2203832.
8. Haixin Chen+, Chaonan Jin+, Xuepeng Chen, Jiangyue Yu, Dong Yan, Peng Cheng, Zhenjie Zhang, Limin Zhao, Yao Chen*, Covalent organic frameworks as crystalline sponges for enzyme extraction and production from natural biosystems, Chem. Eng. J. 2022, 444, 136624.
9. Chaonan Jin, Ning Li, En Lin, Xuepeng Chen, Ting Wang, Yan Wang, Mingfang Yang, Wansheng Liu, Jiangyue Yu, Zhengjie Zhang, Yao Chen*, Enzyme Immobilization in Porphyrinic Covalent Organic Frameworks for Photoenzymatic Asymmetric Catalysis, ACS Catal. 2022, 12, 8259- 8268.
10. Renhao Yang, Yunlong Zheng, Yin Zhang, Gen Li, Yidong Xu, Yin Zhang, Yang Xu, Chengyu Zhuang, Pei Yu, Lianfu Deng, Wenguo Cui*, Yao Chen*, Lei Wang*, Bipolar Metal Flexible Electrospun Fibrous Membrane Based on Metal-Organic Framework for Gradient Healing of Tendon-to-Bone Interface Regeneration, Adv. Healthc. Mater. 2022, 2200072.
11. Jinjin Liu, Zhifang Wang, Peng Cheng, Michael Zaworotko, Yao Chen* and Zhenjie Zhang*, Post-Synthetic Modifications of Metal-Organic Cages, Nat. Rev. Chem. 2022, 6, 339-356.
12. Zhifang Wang, Qianqian Zhu, Jiaxi Wang, Fazheng Jin, Penghui Zhang, Dong Yan, Peng Cheng, Yao Chen*, Zhenjie Zhang*, Industry-compatible covalent organic frameworks for green chemical engineering. Sci. China Chem., 2022, 10.1007/s11426-022-1391-0
13. Zhengfeng Zhao, Yunlong Zheng, Chun Wang, Sainan Zhang, Jie Song, Yafei Li, Shengqian Ma, Peng Cheng, Zhenjie Zhang* and Yao Chen*, Fabrication of Robust Covalent Organic Frameworks for Enhanced Visible-Light-Driven H2 Evolution, ACS Catal. 2021, 11, 2098-2107.
14. Wansheng Liu, Yi Yang, Xiaojie Yang, Yun-Lei Peng, Peng Cheng, Zhenjie Zhang,* and Yao Chen*,Template-Directed Fabrication of Highly Efficient Metal-Organic Framework Photocatalysts, ACS Appl. Mater. Interfaces 2021, 13, 58619-58629.
15. Shan Qiao, Wenjie Duan, Jiangyue Yu, Yunlong Zheng, Dong Yan, Fazheng Jin, Sainan Zhang, Zhenjie Zhang, Haixin Chen, He Huang, and Yao Chen*, Fabrication of Biomolecule Covalent Organic Framework Composites as Responsive Platforms for Smart Regulation of Fermentation Application, ACS Appl. Mater. Interfaces 2021, 13, 32058-32066.
16. Mingmin Li, Shan Qiao, Yunlong Zheng, Yassin H. Andaloussi, Xia Li, Zhenjie Zhang, Ang Li, Peng Cheng, Shengqian Ma, and Yao Chen*, Fabricate Covalent Organic Framework Capsules with Commodious Microenvironment for Enzymes, J. Am. Chem. Soc. 2020, 142, 6675.
17. Wenjie Duan, Shan Qiao, Mingjing Zhuo, Jiaxing Sun, Menglei Guo, Fei Xu, Jinjin Liu, Ting Wang, Xiuxiu Guo, Yan Zhang, Jia Gao, Yueyun Huang, Zhenjie Zhang, Peng Cheng, Shengqian Ma*, Yao Chen*, Multifunctional Platforms: Metal-Organic Frameworks for Cutaneous and Cosmetic Treatment, Chem. 2020, 7, 450-462.
18. Hongde An, Jie Song, Ting Wang, Nannan Xiao, Zhenjie Zhang, Peng Cheng, Shengqian Ma, He Huang, Yao Chen*, Metal-Organic Framework Disintegrants: Enzyme Preparation Platforms with Boosted Activity, Angew. Chem. Int. Ed. 2020, 59, 16764-16769.
19. Huanrong Wang, Lin Han, Dong Zheng, Mingfang Yang, Yassin H. Andaloussi, Peng Cheng, Zhenjie Zhang, Shengqian Ma, Michael J. Zaworotko, Yifan Feng, and Yao Chen*, Protein Structure-Directed Metal-Organic Zeolite-Like Networks as Biomacromolecule Carriers, Angew. Chem. Int. Ed. 2020, 59, 6263.
20. Zhifang Wang, Sainan Zhang, Yao Chen*, Zhenjie Zhang* and Shengqian Ma. Covalent organic frameworks for separation applications, Chem. Soc. Rev. 2020, 391, 44-68.
21. Jingjing Dai, Kaipeng Li, Zongjing Feng, Jun Xu, Yao Chen*, Hongbo Zhang*, Zhenjie Zhang, Evidence on Primary Pore Size Dependence of C–C Bond Coupling Inside Zr-Based Metal-Organic Frameworks. J. Phys. Chem. C 2020, 24, 24713–24722.
22. Juan Xu, Kaipeng Li, Sainan Zhang, Yao Chen*, Lifeng Ning*, Removal of Endocrine- Disrupting Chemicals from Environment Using A Robust Platform Based on Metal− Organic Framework Nanoparticles, ACS Appl. Nano Mater. 2020, 9, 12, 10874-10881.
23. Yu Zhao, Zhifang Wang, Jia Gao, Zhengfeng Zhao, Xia Li, Ting Wang, Peng Cheng, Shengqian Ma, Yao Chen*, Zhenjie Zhang*, COF-Inspired Fabrication of Two-Dimensional Polyoxometalate Based Open Frameworks for Biomimetic Catalysis, Nanoscale 2020, 12, 21218- 21224.
24. Yifan Feng, Huanrong Wang, Sainan Zhang, Yu Zhao, Jia Gao, Yunyi Zheng, Peng Zhao, Zhenjie Zhang, Michael J. Zaworotko, Peng, Cheng, Shengqian Ma*, Yao Chen*, Antibodies@MOFs: An In Vitro Protective Coating for Preparation and Storage of Biopharmaceuticals. Adv. Mater. 2019, 1805148.
25. Jinjin Liu, Wenjie Duan, Jie Song, Xiuxiu Guo, Zhifang Wang, Xinlei Shi, Jiajie Liang, Juan Wang, Peng Cheng, Yao Chen*, Michael J. Zaworotko*, Zhenjie Zhang*. Self-healing Hypercrosslinked Metal–Organic Polyhedra (HCMOPs) Membranes with Antimicrobial Activity and Highly Selective Separation Properties. J. Am. Chem. Soc. 2019, 141, 12064-12070.
26. Zhifang Wang, Qi Yu, Yubo Huang, Hongde An, Yu Zhao, Yifan Feng, Xia Li, Xinlei Shi, Jiajie Liang, Fusheng Pan, Peng Cheng, Yao Chen*, Zhenjie Zhang*, Shengqian Ma*, PolyCOFs: A New Class of Freestanding Responsive Covalent Organic Framework Membranes with High Mechanical Performance, ACS Central Sci. 2019, 5, 1352-1359.
27. Hongde An#, Mingmin. Li#, Jia Gao, Zhenjie Zhang, Shengqian Ma, Yao Chen*, Incorporation of biomolecules in Metal-Organic Frameworks for advanced applications, Coord. Chem. Rev. 2019, 384, 90-106.
28. Cy V. Credille, Yifan Feng, Yao Chen*, Seth Cohen*, SAR Exploration of Tight Binding Inhibitors of Influenza Virus PA Endonuclease, J. Med. Chem. 2019, 62, 21, 9438–9449.
29. Wenjie Duan, Zhengfeng Zhao, Hongde An, Zhenjie Zhang, Peng Cheng, Yao Chen* and He Huang, State of art and prospects of biomolecules-incorporation in functional metal-organic frameworks, Top. Curr. Chem. 2019, 377, 34.
30. Xia Li, Zhifang Wang, Jiaxing Sun, Jia Gao, Yu Zhao, Peng Cheng, Briana Aguila, Shengqian Ma*, Yao Chen*, Zhenjie Zhang*, Squaramide-decorated covalent organic framework as a new platform for biomimetic hydrogen-bonding organocatalysis, Chem. Commun. 2019, 55, 5423- 5426.
31. Puge Zhao, Nannan Liu, Chaonan Jin, Jiaxing Sun, Haixin Chen, Zhenjie Zhang, Limin Zhao*, Peng Cheng, Yao Chen*, UiO-66: An Advanced Platform to Investigate the Influence of Functionalization toward Adsorption Removal of Pharmaceutical Waste, Inorg. Chem. 2019, 58 (13), 8787-8792.
32. Yueyun Huang#, Sainan Zhang#, Haixin Chen, Limin Zhao*, Zhenjie Zhang*, Peng Cheng, Yao Chen*. A Zinc Coordination Complex Mimicking Carbonic Anhydrase for CO2 Hydrolysis and Sequestration. Inorg. Chem. 2019, 58 (15), 9916-9921.
33. Xia Li, Sainan Zhang, Jia Gao, Zhifang Wang, Qi Yu, Yu Zhao, Peng Cheng, Yao Chen*, Zhenjie Zhang*, The recent development and applications of chiral covalent organic frameworks. SCIENTIA SINICA Chimica 2019, 49, (5): 662-671.
34. Sainan Zhang, Yunlong Zheng, Hongde An, Briana. Aguila, Chengxiong Yang, Yueyue Dong, Wei Xie, Peng Cheng, Zhenjie Zhang*, Yao Chen*, Shengqian Ma*, Covalent Organic Frameworks with Chirality Enriched by Biomolecules for Efficient Chiral Separation, Angew. Chem. Int. Ed. 2018, 57, 16754-16759.
35. Chaonan Jin#, Sainan Zhang#, Zhenjie Zhang*, Yao Chen*. Mimic Carbonic Anhydrase Using Metal-Organic Frameworks for CO2 Capture and Conversion. Inorg. Chem. 2018, 57(4): 2169-2174.
36. Yao Chen*, Seongmin Hong, Chung-Wei Fu, Tran Hoang, Xiao Li, Veronica Valencia, Zhenjie Zhang§, Jason A. Perman, Shengqian Ma*, Investigation of Mesoporous Metal-Organic Framework as a new study the Transport phenomena of Biomolecules, ACS Appl. Mater. Inter., 2017, 9(12): 10874-10881.
37. Yao Chen*, Barry Lai, Zhenjie Zhang, Seth M. Cohen*, The effect of metalloprotein inhibitors on cellular metal ion content and distribution, Metallomics 2017, 9(3): 250-257
38. Yao Chen, Lukasz Wojtas, Shengqian Ma, Michael J. Zaworotko*, Zhenjie Zhang*, Post-synthetic transformation of a Zn(II) polyhedral coordination network into a new supramolecular isomer of HKUST-1, Chem. Commun. 2017, 53, 8866-8869.
