Doctor degree, professor, State laboratory of Chemical Medical Biology, graduated from University of Notre Dame
National Science Found for Distinguished Young Scholars
Research Interest：
1.Medicinal Chemistry
2. Target Identification of Complex Natural Products
3. Total Syntheisis of Natural Product
Education History：
1990-1994 Hunan Normal University，B.S., P. R. China;
1994-1997: Shanghai Institute of Organic Chemistry, Chinese Academy of Science, M. S., P. R. China;
1998-2003: University of Notre Dame, Ph. D., USA;
2003-2007: Scientist, Kosan Biosciences, California, USA;
2008.1- 2020.10: Prof. at College of Pharmacy and State laboratory of Chemical Medical Biology, Nankai University, Tianjin, P. R. China.
2020.10-Present: Prof. at College of Chemistry and State laboratory of Chemical Medical Biology, Nankai University, Tianjin, P. R. China
Honors and Awards
Awardee of The National Science Fund for Distinguished Young Scholars;
Awardee of Fok Ying-Tong Education Foundation;
Program for New Century Excellent Talents in University;
Hundred Young Academic Leaders Program of Nankai University.
Scientific Achievements & Selected Publications
1. Bolin Chen, Qianwei Wu, Dongdong Xu, Xijing Zhang, Yahui Ding, Shiqi Bao, Xuemei Zhang, Liang Wang*, Yue Chen* , A Two-Phase Approach to Fusicoccane Synthesis To Uncover a Compound That Re duces Tumourigenesis in Pancreatic Cancer Cells, Angew. Chem. Int. Ed. 2022, 61, e202117476.
2. Junhong Xiang, Yahui Ding,* Jiaxin Li, Xiuhe Zhao, Yuanjun Sun, Da Wang, Liang Wang* ,Yue Chen*, Ovatodiolides: Scalable Protection-free Syntheses, Configuration Determination and Biological Evaluation against Hepatic Cancer Stem Cells, Angew. Chem. Int. Ed. 2019, 58, 10587-10590.
3. Jing Li, Shanshan Li, Jianshuang Guo, Qiuying Li, Jing Long, Cheng Ma, Yahui Ding, Chunli Yan, Liangwei Li, Zhigang Wu, He Zhu, Keqin Li, Liuqing Wen, Quan Zhang, Qingqing Xue, Caili Zhao, Ning Liu, Ivaylo Ivanov, Ming Luo, Rimo Xi, Haibo Long, Peng Wang*, Yue Chen*, Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia, J. Med. Chem. 2018, 61, 4155-4164. (Editor’s choice)
4. Yuanjun Sun,# Yahui Ding,# Dongmei Li, Ruifei Zhou, Xiuwen Su, Juan Yang, Xiaoqian Guo, Chuanke Chong, Jinghan Wang, Weicheng Zhang, Cuigai Bai, Liang Wang*, Yue Chen*, Cyclic Depsipeptide BE-43547A2: Synthesis and Activity against Pancreatic Cancer Stem Cells, Angew. Chem. Int. Ed. 2017, 56, 14627-14631（Hot paper, Press Release Paper, comments: the successful synthesis of BE-43547A2 may be a decisive step in the ongoing pancreatic cancer）
5. Yingjun Cui, Mengyi Zhang, Honglei Xu, Tingrong Zhang, Songming Zhang, Xiuhe Zhao, Peng J iang, Jing Li, Baijun Ye, Yuanjun Sun, Mukuo Wang, Yangping Deng, Qing Meng, Yang Liu, Qiang Fu, Liang Wang*, Yue Chen*, Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo 2 Bio logical Evaluation for Acute Lung Injury, J. Med. Chem. 2022, 65, 2971-2987.
