Doctor degree, professor, State laboratory of Medical Chemical Biology, graduated from Nankai University

National Science Found for Outstanding Young Scholars

Research Interest：The development of novel materials by self-assembling peptides for biomedical applications.

Education History：

2004-2008, School of Materials Science and Engineering, Tianjin University, Bachelor of Materials Science.

2008-2013，College of Life Sciences, Nankai University，Doctor of Chemisty.

Honors and Awards

Ÿ   100 of Young Academic Pacemaker, 2022

Ÿ   National Science Fund for Outstanding Young Scholars, 2021

Ÿ   Young Elite Scientists Sponsorship Program by Tianjin, 2017

Ÿ   Acdemic Excellent Scholarship, 2008

Ÿ   LG Scholarship, 2006

Scientific Achievements & Selected Publications

(1)        Jie Gao, Huaimin Wang, Ling Wang, Jingyu Wang, Deling Kong*, Zhimou Yang*, Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule, Journal of the American Chemical Society, 2009, 131(32): 11286-11287

(2)        Wenting Zheng^#, Jie Gao^#, Lijie Song, Chongyi Chen, Di Guan, Zhihong Wang, Zhibo Li*, Deling Kong*, Zhimou Yang*, Surface-Induced Hydrogelation Inhibits Platelet Aggregation, Journal of the American Chemical Society, 2013, 135(1): 266-271

(3)        Jie Gao^#, Wenting Zheng^#, Jimin Zhang, Di Guan, Zhimou Yang*, Deling Kong, Qiang Zhao*, Enzyme-controllable delivery of nitric oxide from a molecular hydrogel, Chemical Communications, 2013, 49(80): 9173-9175

(4)        Jie Gao, Yang Shi, Youzhi Wang, Yanbin Cai, Jie Shen*, Deling Kong*, Zhimou Yang*, Enzyme-controllable F-NMR turn on through disassembly of peptide-based nanospheres for enzyme detection, Organic and Biomolecular Chemistry, 2014, 12(9): 1383-1386

(5)        Jie Gao, Wenting Zheng, Deling Kong*, Zhimou Yang*, Dual Enzymes Regulate the Molecular Self-assembly of Tetra-Peptide Derivatives, Soft Matter, 2011, 7(21): 10443-10448

(6)        Yanbin Cai, Haosheng Shen, Jie Zhan, Mingliang Lin, Liuhan Dai, Chunhua Ren, Yang Shi，Jianfeng Liu*, Jie Gao*, Zhimou Yang*, Supramolecular “Trojan Horse” for Nuclear Delivery of Dual Anticancer Drugs, Journal of the American Chemical Society, 2017, 139(8): 2876−2879

(7)        Guoqin Chen^#, Jinliang Li^#, Mingcai Song, Zhiye Wu, Wenzhu Zhang, Zhongyan Wang, Jie Gao*, Zhimou Yang* and Caiwen Ou*, A mixed component supramolecular hydrogel to improve mice cardiac function and alleviate ventricular remodeling after acute myocardial infarction, Advanced Functional Materials, 2017, 27 (34): 1701798.

(8)        Zhongyan Wang, Yanbin Cai, Linan Yi, Jie Gao*, Zhimou Yang*, Supramolecular Hydrogels of Indole-Capped Short Peptides as Vaccine Adjuvants, Chinese Journal of Chemistry, 2017, 35(7): 1057-1062

(9)        Jie Zhan^#, Yanbin Cai^#, Shenglu Ji, Yuna Shang, Jie Gao*, Zhimou Yang*, Supramolecular silk from a peptide hydrogel，Materials Chemistry Frontiers, 2017, 1(5): 911-915

(10)    Jingyu Wang, Jing Zheng, Yanbin Cai, Jinxin Zheng, Jie Gao*, Qingqiu Gong*, Zhimou Yang*, Imaging Cellular Distribution of Fluorescent Supramolecular Nanofibers, Science China Chemistry，2015, 59(6): 719-723

(11)    Chao Xu, Yanbin Cai, Chunhua Ren, Jie Gao*, Jihui Hao*, Zinc-Triggered Hydrogelation of Self-assembled Small Molecules to Inhibit Bacterial Growth, Scientific Reports, 2015, 5: 7753-7759

(12)    Guoqin Chen^#, Jiaxin Chen^#, Qicai Liu, Caiwen Ou*, Jie Gao*, Enzymatic Formation of a Meta-stable Supramolecular Hydrogel for 3D Cell Culture, RSC Advances, 2015, 5(39): 30675-30678

(13)    Li, H.^#; Gao, J.^#; Shang, Y.; Hua, Y.; Ye, M.; Yang, Z.*; Ou, C.*; Chen, M.*, Folic Acid Derived Hydrogel Enhances the Survival and Promotes Therapeutic Efficacy of iPS Cells for Acute Myocardial Infarction, ACS Appl. Mater. Interfaces, 2018, 10 (29): 24459-24468. (#equal contribution)

(14)    Zhang, Y.; Pan, Y.-C.; Wang, Y.; Guo, D.-S.*; Gao, J.*; Yang, Z., Fast naked-eye detection of zinc ions by molecular assembly-assisted polymerization of diacetylene, Nanoscale, 2018, 10 (39): 18829-18834.

(15)    Gao, J.; Zhan, J.; Yang, Z., Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides, Adv. Mater, 2019, 0 (0): 1805798.

(16)    Shang, Y.; Zhi, D.; Feng, G.; Wang, Z.; Mao, D.; Guo, S.; Liu, R.; Liu, L.; Zhang, S.; Sun, S.; Wang, K.*; Kong, D.; Gao, J.*; Yang, Z.*, Supramolecular Nanofibers with Superior Bioactivity to Insulin-Like Growth Factor-I, Nano Lett., 2019, 19 (3): 1560-1569.

(17)    Shang, Y.; Liao, Y.; Ye, Z. J.; Wang, Z. Y.; Xiao, L.; Gao, J.*; Wang, Q.*; Yang, Z.*, Supramolecular protein glue to boost enzyme activity, Sci. China Mater., 2019, 62 (9): 1341-1349.

(18)    Gao, J.; Gu, Z.*, Toward nanoscopic cellular imaging by X-ray, Natl. Sci. Rev., 2020, nwaa206.

(19)    Liang, C.; Wang, Z.; Xu, T.; Chen, Y.; Zheng, D.; Zhang, L.; Zhang, W.; Yang, Z.; Shi, Y.*; Gao, J.*, Preorganization Increases the Self-Assembling Ability and Antitumor Efficacy of Peptide Nanomedicine. ACS Appl, Mater. Interfaces, 2020, 12 (20): 22492-22498.

(20)    Feng, K.; Ma, C.; Liu, Y.; Yang, X.; Yang, Z.; Chen, Y.; Xu, T.; Yang, C.; Zhang, S.; Li, Q.; Wei, Z.; Zhao, D.; Zeng, P.; Han, J.; Gao, J.*; Chen, Y.*; Duan, Y.*, Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis, Theranostics, 2021, 11 (6): 2634-2654.

(21)    Shang, Y.; Liu, H.; Peng, R.; Ren, C.; Luo, X.; Ma, C.; Gao, Y.; Wang, Z.; Gao, J.*; Liu, J.*; Yang, Z.*, PDGF-mimicking supramolecular nanofibers for ionizing radiation-induced injury repair, Chem. Eng. J., 2021, 410, 128309.

(22)    Zhang, Y.; Ding, Y.; Li, X.; Zheng, D.; Gao, J.*; Yang, Z.*, Supramolecular hydrogels of self-assembled zwitterionic-peptides, Chin. Chem. Lett., 2021.

(23)    Zheng, D.; Liu, J.; Ding, Y.; Xie, L.; Zhang, Y.; Chen, Y.; Peng, R.; Cai, M.; Wang, L.; Wang, H.*; Gao, J.*; Yang, Z.*, Tandem molecular self-assembly for selective lung cancer therapy with an increase in efficiency by two orders of magnitude, Nanoscale, 2021, 13 (24): 10891-10897.

(24)    Ai, S.; Li, H.; Zheng, H.; Liu, J.; Gao, J.*; Liu, J.*; Chen, Q.*; Yang, Z.*, A SupraGel for efficient production of cell spheroids, Sci. China Mater., 2022.

(25)    Li, X.; Wang, Y.; Zhang, Y.; Yang, Z.; Gao, J.*; Shi, Y.*, Enzyme Instructed Self-assembly (EISA) Assists the Self-assembly and Hydrogelation of Hydrophobic Peptides, J. Mater. Chem. B., 2022.

(26)    Zhang, Y.; Yu, Y.; Gao, J.*, Supramolecular Nanomedicines of In-Situ Self-Assembling Peptides, Frontiers in Chemistry, 2022, 10.

(27)    Yang, C.; Mu, G.; Zhang, Y.; Gao, Y.; Zhang, W.; Liu, J.; Zhang, W.; Li, P.; Yang, L.; Yang, Z.; Gao, J.*; Liu, J.*, Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization. Adv. Mater. 2022, 2202625.