Education &Research History：
2020-Present Full Professor, College of Life Sciences, Nankai University.
2020-Present Principle investigator, State Key Laboratory of Medicinal Chemical Biology.
2017-2018 Visiting Scholar, Medical School, Stanford University.
2015-2020 Associate Professor, College of Pharmacy, Nankai University.
2012-2015 Lecturer, College of Pharmacy, Nankai University.
2010-2012 Ph.D., College of Life Sciences, Nankai University
2003-2007 B.A., College of Life Sciences, Nankai University.
Research Interest:
Yu's laboratory is broadly interested in the entry mechanism and host defense of viruses infection. Our principal goal is to exploit mechanistic and structural information on virus-host interactions, and provide innovative solutions to disease prevention and therapeutics. We develop structural and functional tools to study macro-molecular assemblies such as virus particle, virus-antibody complex and ligand-receptor complex, and combine both of experimental and computational approaches to address critical questions in virology and immunology research.
Honors and Awards：
2021 elected：The National "Ten Thousand Talents Program" for Young Outstanding Talents
2021 received: The Tianjin Youth Science and Technology Award
2020 elected：The China Association for Science and Technology's "Young Talent Nurturing Project."
Scientific Achievements & Selected Publications
1. Guo Yu*, et.al, Rao Zihe*, Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nature Communications, 2023, 14(1):3537.
2. Guo Yu*, et.al, Rao Zihe*, A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nature Communications, 2021, 12(1): 2623-2623.
3. Fu Dan, et.al, Guo Yu*, Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes. PLoS biology, 2021, 19(5) : e3001209-e3001209.
4. Zhou Xingdong, et.al, Guo Yu*, Hongkai Zhang*, Xiaoming Yang*, Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine. Protein & cell, 2021: 1-6.
5. Li Guobang, et.al, Guo Yu*, Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly. Protein & Cell, 2020, 11(8) : 600-605.
6. Fu Dan, et.al, Guo Yu*, Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding. Protein & Cell, 2020, 11(8) : 606-612.
7. Li Guobang, et.al, Guo Yu*, Crystal structure of the African swine fever virus pS273R protease and implications for inhibitor design. Journal of Virology, 2020, 94(10)
8. Zhang Min, et.al, Guo Yu*, Design, Synthesis, and Evaluation of Novel Enterovirus 71 Inhibitors as Therapeutic Drug Leads for the Treatment of Human Hand, Foot and Mouth Disease. Journal of Medical Chemistry, 2020, 63(3) : 1233-1244.
9. Li Guobang, et.al, Guo Yu*, Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family. Journal of Virology, 2020, 94(4).
