Research Interest:
1) Active substances and efficacy natural medicines including the discovery, structure-activity relationship, and biological activity and mechanism of action.
2) The discovery of lead molecules from natural medicines.
3) The research and development of new drugs.
Education History:
1996-2000, Harbin University of Commerce, Bachelor of Chemistry;
2000-2004, College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Doctor of Medicinal Chemistry
Honors and Awards
Scientific Achievements & Selected Publications
1) Shaojie Zhang, Yeling Li, Zhengguo Li, Jing Xu* and Yuanqiang Guo*. Structure, anti-tumor activity, and potential anti-tumor mechanism of a fungus polysaccharide from Fomes officinalis. Carbohydrate Polymers, 2022, 295: 119794 (Corresponding author).
2) Shaojie Zhang, Ziteng Song, Lijuan Shi, Jing Xu* and Yuanqiang Guo*.A dandelion polysaccharide and its selenium nanoparticles: Structure features and evaluation of anti-tumor activity in zebrafish models. Carbohydrate Polymers, 2021, 270: 118365 (Corresponding author).
3) Yinan Zhao, Xuke Zhang, Ying Li, Jing Xu* and Yuanqiang Guo*. A natural xanthone suppresses lung cancer growth and metastasis by targeting STAT3 and FAK signaling pathways. Phytomedicine, 2022, 102: 154118 (Corresponding author).
4) Xuke Zhang, Ziteng Song, Ying Li, Jing Xu* and Yuanqiang Guo*. Cytotoxic and antiangiogenetic xanthones inhibiting tumor proliferation and metastasis from Garcinia xipshuanbannaensis. Journal of Natural Products, 2021, 84(5): 1515-1523 (Corresponding author).
5) Min Du, Lijun An, Jing Xu,* and Yuanqiang Guo*. Euphnerins A and B, diterpenoids with a 5/6/6 rearranged spirocyclic carbon skeleton from the stems of Euphorbia neriifolia. Journal of Natural Products 2020, 83(9): 2592−2596 (Corresponding author).
6) Zhengguo Li, Lijun An, Shaojie Zhang, Jing Xu* and Yuanqiang Guo*. Structural elucidation and immunomodulatory evaluation of a polysaccharide from Stevia rebaudiana leaves. Food Chemistry, 2021, 364: 130310 (Corresponding author).
