Research Interest:
Our aim is to investigate the interaction between nanomaterials and biological barriers, and to solve the problems in oncology and regenerative medicine. The representative technologies in our lab include genetic engineered ferritin nanocages, antibody-engineered cell membrane nanomedicines, Artificial Intelligence (AI)-assisted nanotechnology. The interest topics are following.
1. Biological effects of nanomaterials.
The main current theme of our lab is to understand whether and how nanomaterials penetrate various physiological or pathological barriers, to study active regulation effect of bioactive nanomaterials; to explore how nanomedicines regulate body immune system.
2. Tumor diagnosis and treatment.
The main current theme of our lab is to design biomimetic nanomedicines for tumor theranostics by integrating synthetic biology, machine learning with nanotechnology.
3. Tissue engineering and regenerative medicine.
The main current theme of our lab is to create bioactive nanomaterials for modulation of vascular regeneration in ischemic tissues; to develop nanomedicines for the prevention and treatment of Alzheimer’s disease.
Education History：
2000-2002, Shandong Agriculture University
2004-2007, Shanxi Agriculture University, Master
2007-2010, Technical Institute of Physics and Chemistry, Chinese Academy of Science, Doctor.
Honors and Awards
Selected Publications
1. Zhu M, Zhuang J, Li Z, Liu Q, Gao Z, Midgley AC, Qi T, Zhao R, Zhang Z, Kong D, Tian J*, Yan X*, Huang X*. Machine Learning-assisted Single Vessel Analysis of Nanoparticle Permeability in Tumour Vasculatures. Nature Nanotechnology. 2023, 10.1038/ s41565-023-01323-4.
2. Wei Y, Wu J, Wu Y, Liu H, Meng F, Liu Q, Midgley AC, Zhang X, Qi T, Kang H, Chen R, Kong D, Zhuang J, Yan X, Huang X*. Prediction and Design of Nanozymes using Explainable Machine Learning. Advanced Materials. 2022, 34:e2201736.
3. Zhang X, Zhang Y, Zhang R, Jiang X, Midgley AC, Liu Q, Kang H, Wu J, Khalique A, Qian M, An D, Huang J, Ou L, Zhao Q, Zhuang J, Yan X, Kong D, Huang X*. Biomimetic Design of Artificial Hybrid Nanocells for Boosted Vascular Regeneration in Ischemic Tissues. Advanced Materials. 2022, 34:e2110352.
4. Liu Q, Tian J, Liu J, Zhu M, Gao Z, Hu X, Midgley AC, Wu J, Wang X, Kong D, Zhuang J, Liu J, Yan X, Huang X*. Modular Assembly of Tumor-penetrating and Oligomeric Nanozyme based on Intrinsically Self-assembling Protein Nanocages. Advanced Materials. 2021, 5:e2103128.
5. Zhang R, Luo W, Zhang Y, Zhu D, Midgley AC, Song H, Khalique A, Zhang H, Zhuang J, Kong D*, Huang X*. Particle-based Artificial Three-dimensional Stem Cell Spheroids for Revascularization of Ischemic Diseases. Science Advances. 2020, 6:eaaz8011.
