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李昌华 教授Changhua Li, PhD
Professor of Chemistry, State laboratory of Chemical Medical Biology. He obtained his BS and PhD degree from the University of Science and Technology of China (USTC) in 2007 and 2012, respectively.
Special Talent:
Address: State Key Laboratory of Medicinal Chemical Biology, Nankai University
Telephone: +86-22-85358328
Email: chli@nankai.edu.cn
Research Group Website:

Education &Research History

2023- , Professor, Nankai University

2015-2023, Researcher, Nankai University

2012-2015, JSPS Researcher, The University of Tokyo; RIKEN

2007-2012, PhD, University of Science and Technology of China (USTC)

2003-2007, BS, University of Science and Technology of China (USTC)

Research Interest:

He has long been engaged in the development of new types of sensing/activating mechanisms and general strategies for the preparation of organic polymeric and supramolecular biomedical materials for in vivo cancer diagnosis and treatment. His research interests include highly fluorogenic bioprobes for chemical biology research, smart nanotheranostics for precise treatments of cancer, and advanced optofunctional materials based on functional dyes through supramolecular approaches. His research aims to guide and promote the preparation of new high-performance diagnostic and therapeutic materials, providing research tools for the quantitative detection of biochemical processes and the dynamic measurement of bioactive molecules in complex living systems, and affording possible solutions for early diagnosis and precise treatment of cancer.

Honors and Awards

      2021, Granted by Youqing Fund of NSFC

      2019, Young Science and Technology Innovation Talents of Tianjin

      2016, First Prize of Anhui Science and Technology Award, Anhui Province

      2013, Chinese Academy of Sciences (CAS) Excellent Doctoral Dissertation

      2012, Chinese Academy of Sciences (CAS) President’s Special Award

      2012, Outstanding Graduate Students Award

      2011, Qiushi Scholarship

      2010, Young Talented PhD Students Award

Scientific Achievements & Selected Publications

He has published 35 SCI-indexed papers, and the total SCI citations of his authored publications were over 2300.

 

1.   S. X. Li,# X. S. Yan,# J. Q. Zhang, X. Guo, Y. K. Zhang, M. H. Su, C. Yang, H. Zhang, C. H. Li* " J-Aggregation-Driven Supramolecular Assembly of Dye-Conjugated Block Polymers: From Morphological Tailoring to Anticancer Applications " Adv. Funct. Mater. 2021, 31, 2105189.

2.   M. H. Su,# Q. J. Han,# X. S. Yan, Y. N. Liu, P. Luo, W. H. Zhai, Q. Z. Zhang*, L. Y. Li, C. H. Li* "A Supramolecular Strategy to Engineering a Non-photobleaching and Near-Infrared Absorbing Nano-J-Aggregate for Efficient Photothermal Therapy" ACS Nano 2021, 15, 5032-5042.

3.   X. S. Yan,# M. H. Su,# Y. N. Liu, Y. K. Zhang, H. Zhang, C. H. Li* "Molecularly Engineered Hierarchical Nanodisc from Antiparallel J−stacked BODIPY Conjugates: Application to Theranostics with Mutually Beneficial Properties" Adv. Func. Mater. 2021, 31, 2008406.

4.    C. Yang, M. H. Su, P. Luo, Y. N. Liu, F. Yang, C. H. Li* “A Photosensitive Polymeric Carrier with a Renewable Singlet Oxygen Reservoir Regulated by Two NIR Beams for Enhanced Antitumor Phototherapy” Small 2021, 17, 2101180.

5.    M. H. Su, S. X. Li, H. Zhang, J. Q. Zhang, H. L. Chen, C. H. Li* "Nano-Assemblies from J-Aggregated Dyes: A Stimuli-Responsive Tool Applicable to Living Systems" J. Am. Chem. Soc. 2019, 141, 402-413.

6.   W. H. Zhai, Y. K. Zhang, M. Liu, H. Zhang, J. Q. Zhang, C. H. Li* “Universal Scaffold for an Activatable Photosensitizer with Completely Inhibited Photosensitivity” Angew. Chem. Int. Ed. 2019, 58, 16601-16609.

7.   H. L. Chen, X. J. He, M. H. Su, W. H. Zhai, H. Zhang, C. H. Li* "A General Strategy Toward Highly Fluorogenic Bioprobes Emitting across the Visible Spectrum" J. Am. Chem. Soc. 2017, 139, 10157-10163.

8.    C. H. Li, T. Wu, C. Y. Hong, G. Q. Zhang*, S. Y. Liu* "A General Strategy to Construct Fluorogenic Probes from Charge-Generation Polymers (CGPs) and AIE-Active Fluorogens via Triggered Complexation" Angew. Chem. Int. Ed. 2012, 51, 455-459. (Highlighted by ACS Noteworthy Chemistry)

9.   C. H. Li, Y. X. Zhang, J. M. Hu, J. J. Cheng*, S. Y. Liu* "Reversible Three-State Switching of Multicolor Fluorescence Emission by Multiple Stimuli Modulated FRET Processes within Thermoresponsive Polymeric Micelles" Angew. Chem. Int. Ed. 2010, 49, 5120-5124.