Prof. Ph.D.
State Key Laboratory of Medicinal Chemical Biology
National Science Found for Distinguished Young Scholars
Research Interest：
Study on reproductive aging and egg senescence, molecular mechanisms underlying early embryo development and differentiation, telomere biology, and derivation and understanding biology of patient-specific stem cells (e.g. parthenogenetic and induced pluripotent stem cells) that might be useful for regenerative medicine, particularly for treatment of reproductive aging and associated diseases.
Education History：
1980-1984，Animal Science and Technology College ，Jiangxi Agricultural University，Bachelor of Animal Science and Veterinary Medicine
1984-1987，Animal Science and Technology College, Jiangxi Agricultural University，Master of Animal Physiology and Biochemistry
1990-1993，Beijing Agricultural University (now China Agricultural University)，Doctor of Reproductive Physiology and Biotechnology
Honors and Awards:
Dr. Liu has served as editorial board of several journals in biology and reproductive biology, and received prominent awards, including Outstanding Youth Foundation of China National Natural Science Foundation in 2005 and Changjiang Scholar Program Professor appointed by Ministry of Education of China in 2003. He has published over 100 papers in the related fields in peer reviewed international journals.
Scientific Achievements & Selected Publications
1. Chenglei Tian, Jing Wang, Xiaoying Ye, Jiyu Chen, Rongyan Zheng, Hanwen Yu, Jie Li, Guoxing Yin, Linlin Liu, Nannan Zhao, Guofeng Feng, Zhengmao Zhu, Jichang Wang, Guoping Fan, Lin Liu. ESCs culture conditions impact the tumor appearance in vivo. Cell Rep. 2023 Jun 13;42(6):112645.
2. Nannan Zhao, Guoxing Yin, Chun Liu, Weiyu Zhang, Yang Shen, Dan Wang, Zhenzhen Lin, Jiao Yang, Jian Mao, Renpeng Guo, Yongwang Zhang, Feng Wang, Zhe Liu, Xinyi Lu, Lin Liu. Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells. Cell Discov. 2023 May 2;9(1):45.
3.Chenglei Tian, Dai Heng , Nannan Zhao, Linlin Liu, Xiaoyan Sheng, Jiyu Chen, Lin Liu. Short telomeres impede germ cell specification by upregulating MAPK and TGFβ signaling. Sci China Life Sci. 2022 Sep 16. 66(2):324-339.
4. Chenglei Tian, Linlin Liu, Ming Zeng, Xiaoyan Sheng, Dai Heng, Lingling Wang, Xiaoying Ye, David L. Keefe, Lin Liu. Generation of developmentally competent oocytes and fertile mice from parthenogenetic embryonic stem cells. Protein Cell. 2021, 12(12):947–964.
5. Fu H, Zhang W, Li N, Yang J, Ye X, Tian C, Lu X, Liu L: Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells. Genome Biol 2021, 22(1):201.
6. Wang H, Gong P, Chen T, Gao S, Wu Z, Wang X, Li J, Marjani SL, Costa J, Weissman SM, Qi F, Pan X, Liu L: Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single-Cell Analysis of Transcriptome and Telomeres. Adv Sci (Weinh) 2021, 8(8):2004320.
7. Tian C, Liu L, Ye X, Fu H, Sheng X, Wang L, Wang H, Heng D, Liu L: Functional Oocytes Derived from Granulosa Cells. Cell Rep 2019, 29(13):4256-4267 e4259.
8. Zhang W, Chen F, Chen R, Xie D, Yang J, Zhao X, Guo R, Zhang Y, Shen Y, Goke J, Liu L, Lu X: Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes. Nucleic Acids Res 2019, 47(16):8485-8501.
9. Zhou Z, Wang L, Ge F, Gong P, Wang H, Wang F, Chen L, Liu L: Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res 2018, 46(7):3468-3486.
10. Guo R, Ye X, Yang J, Zhou Z, Tian C, Wang H, Wang H, Fu H, Liu C, Zeng M, Yang J, Liu L: Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells. Nat Commun 2018, 9(1):2620.
11. Liu L: Linking Telomere Regulation to Stem Cell Pluripotency. Trends Genet 2017, 33(1):16-33.
12. Yang J, Guo R, Wang H, Ye X, Zhou Z, Dan J, Wang H, Gong P, Deng W, Yin Y, Mao S, Wang L, Ding J, Li J, Keefe DL, Dawlaty MM, Wang J, Xu G, Liu L: Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs. Cell Rep 2016, 15(8):1809-1821.
13. Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, Gao S, Liu L, Chen L: Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A 2015, 112(44):E5936-5943.
14. Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A, Liu L: Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell 2014, 29(1):7-19.
15.Wang F, Pan X, Kalmbach K, Seth-Smith ML, Ye X, Antumes DM, Yin Y, Liu L, Keefe DL, Weissman SM: Robust measurement of telomere length in single cells. Proc Natl Acad Sci U S A 2013, 110(21):E1906-1912.
16. Jiang J, Lv W, Ye X, Wang L, Zhang M, Yang H, Okuka M, Zhou C, Zhang X, Liu L, Li J: Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation. Cell Res 2013, 23(1):92-106.
17. Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L: Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Res 2012, 22(4):757-768.
18. Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L: Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res 2011, 21(5):779-792.
19. Liu L, Bailey SM, Okuka M, Munoz P, Li C, Zhou L, Wu C, Czerwiec E, Sandler L, Seyfang A, Blasco MA, Keefe DL: Telomere lengthening early in development. Nat Cell Biol 2007, 9(12):1436-1441.
20. Liu L, Franco S, Spyropoulos B, Moens PB, Blasco MA, Keefe DL: Irregular telomeres impair meiotic synapsis and recombination in mice. Proc Natl Acad Sci U S A 2004, 101(17):6496-6501.
21. Liu L, Oldenbourg R, Trimarchi JR, Keefe DL: A reliable, noninvasive technique for spindle imaging and enucleation of mammalian oocytes. Nat Biotechnol 2000, 18(2):223-225.
