Research Interest：Structural basis for the pathogenicity of infectious agents and structure-based drug discovery.
Education History：
2000-2004，College of Science, Tianjin University，Bachelor of Physics
2005-2007，College of Physics, Peking University，Master of Bio-physics
2007-2011，College of Life Sciences, Peking University，Doctor of Philosophy
Scientific Achievements & Selected Publications
1. Y. Zhao, Y. Zhu, X. Liu*, Z. Jin, Y. Duan, Q. Zhang, C. Wu, L. Feng, X. Du, J. Zhao, M. Shao, B. Zhang, X. Yang, L. Wu, X. Ji, L.W. Guddat, K. Yang, Z. Rao, H. Yang, Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2, Proc Natl Acad Sci U S A, 119 (2022) e2117142119.
2. Q. Zhang, X. Liu*, H. Liu, B. Zhang, H. Yang, K. Mi, L.W. Guddat, Z. Rao, Conformational Changes in a Macrolide Antibiotic Binding Protein From Mycobacterium smegmatis Upon ADP Binding, Front Microbiol, 12 (2021) 780954.
3. M. Wei, Y. Zhou, C. Li, Y. Yang, T. Liu, Y. Liu, Y. Wei, N. Liu, S. Liu, Q. Wang, S. Cao, Y. Sun, P. Sheng, C. Lu, C. Yang, X. Liu*, G. Yang, 5alpha-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2, J Med Chem, (2021).
4. Z. Jin, X. Du, Y. Xu, Y. Deng, M. Liu, Y. Zhao, B. Zhang, X. Li, L. Zhang, C. Peng, Y. Duan, J. Yu, L. Wang, K. Yang, F. Liu, R. Jiang, X. Yang, T. You, X. Liu*, X. Yang, F. Bai, H. Liu, X. Liu, L.W. Guddat, W. Xu, G. Xiao, C. Qin, Z. Shi, H. Jiang, Z. Rao, H. Yang, Structure of M(pro) from COVID-19 virus and discovery of its inhibitors, Nature, (2020).
5. W. Dai, B. Zhang, H. Su, J. Li, Y. Zhao, X. Xie, Z. Jin, F. Liu, C. Li, Y. Li, F. Bai, H. Wang, X. Cheng, X. Cen, S. Hu, X. Yang, J. Wang, X. Liu*, G. Xiao, H. Jiang, Z. Rao, L.K. Zhang, Y. Xu, H. Yang, H. Liu, Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease, Science, (2020).
6. X. Chen, J. Chen, B. Yan, W. Zhang, L.W. Guddat, X. Liu*, Z. Rao, Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria, Proc Natl Acad Sci U S A, 117 (2020) 16324-16332
