Research Interest：Viral Infection and Immunity
Education History：
1990-1994，Biological College, Chinese Agriculture University，Bachelor of Biology
1994-1999， Institute of Biophysics, Chinese Academy of Sciences，Doctor of Molecular Biology
Honors and Awards
Scientific Achievements & Selected Publications
1. Ji W, Zhang L, Ma C, Xu X, Li S, Xia H, Zhou W, Liu X. Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis. Cell Rep. 2023 Mar 30;42(4):112327. doi: 10.1016/j.celrep.2023.112327.
2. Wu Y, Chang Y, Luo L, Tian W, Gong Q, Liu X. Abscisic acid employs NRP-dependent PIN2 vacuolar degradation to suppress auxin-mediated primary root elongation in Arabidopsis. New Phytol. 2022 Jan;233(1):297-312. doi: 10.1111/nph.17783.
3. He TS, Dang L, Zhang J, Zhang J, Wang G, Wang E, Xia H, Zhou W, Wu S, Liu X. The Hippo signaling component LATS2 enhances innate immunity to inhibit HIV-1 infection through PQBP1-cGAS pathway. Cell Death Differ. 2022 Jan;29(1):192-205. doi: 10.1038/s41418-021-00849-1.
4. Ji W, Zhang L, Xu X, Liu X. ALG2 regulates type I interferon responses by inhibiting STING trafficking. J Cell Sci. 2021 Dec 15;134(24):jcs259060. doi: 10.1242/jcs.259060.
5. Lu J, Jia J, Zhang J, Liu X. HIV p17 enhances T cell proliferation by suppressing autophagy through the p17-OLA1-GSK3β axis under nutrient starvation. J Med Virol. 2021 Jun;93(6):3607-3620. doi: 10.1002/jmv.26423.
6. Ji W, Xin Y, Zhang L, Liu X. ALG2 Influences T cell apoptosis by regulating FASLG intracellular transportation. Biochem J. 2020 Aug 28;477(16):3105-3121. doi: 10.1042/BCJ20200028.
7. He TS, Ji W, Zhang J, Lu J, Liu X. ALG-2 couples T cell activation and apoptosis by regulating proteasome activity and influencing MCL1 stability. Cell Death Dis. 2020 Jan 2;11(1):5. doi: 10.1038/s41419-019-2199-4.
8. Li X, Li L, Chang Y, Ning W, Liu X. Structural and functional study of FK domain of Fstl1. Protein Sci. 2019 Oct;28(10):1819-1829. doi: 10.1002/pro.3696.
9. Zhang Y, Lu J, Ma J, Liu X. Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8. J Biol Chem. 2019 Feb 8;294(6):2046-2059. doi: 10.1074/jbc.RA118.004630.
10. Zhu T., Wu Y., Yang X., Chen W., Gong Q., and Liu X. The Asparagine-rich Protein NRP Facilitates the Degradation of the PP6-type Phosphatase FyPP3 to Promote ABA Response in Arabidopsis. Mol. Plant. 2018 Feb 5;11(2):257-268. doi: 10.1016/j.molp.2017.11.006.
