Research Interest：
Research in the laboratory has focused on epigenetic gene regulation and disease, and we are also interest in structure-based protein engineering in cancer therapy application.
Education History：
1995-1999，College of Life Sciences, Nankai University，Bachelor of Biochemistry and Molecular Biology
1999-2004， Hong Kong University of Science and Technology，Doctor of Biochemistry
Honors and Awards:
1. Fist Prize of the Tianjin Natural Science Award (Ranked Fifth) (2014)
2. Winners in the Thirteenth Tianjin Youth Science and Technology (2016)
3. Sanofi-Cell Research Outstanding Paper Award (2016)
4. Tang Cornell-China Scholar (2019)
Scientific Achievements
Currently, a series of interesting results have been obtained regarding the molecular mechanism of histone modification complex assembly, the regulatory mechanism of chromatin remodeling and liquid-liquid phase separation in human disease. From the angle of biochemistry and structural biology, these results promoted the epigenetic mechanism of multi-protein complexes involved in the regulation of gene expression, and make some contribution to the development of science. We have published original research articles in Nat Struc Mol Biol, Nat Commun, PNAS, Cell Res, Nucleic Acid Res, Cell Discov, Structure, FASEB J, JBC, and among others.
Selected Publications (*: Corresponding author)
1. Chen, F., Liu, B., Zhou, H., Long, J.*, The Paf1 complex is required for RNA polymerase II removal in response to DNA damage, Proc. Natl. Acad. Sci. USA, 119(40): e2207332119 (2022).
2. Cheng, Y., Shen, Z., Gao, Y., Chen, F., Xu, H., Mo, Q., Chu, X., Peng, C-L., Mckenzie, T., Palacios, B., Hu, J., Zhou, H.*, Long, J.*, Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas, Nat. Commun., 13(1):2724 (2022).
3. Chen, F., Liu, B., Guo, L., Ge, X., Feng, W., Li, D-F*, Zhou, H.*, Long, J.*, Biochemical insights into Paf1 complex-induced stimulation of Rad6/Bre1-mediated H2B monouqbiquitination, Proc. Natl. Acad. Sci. USA, 118(33): e2025291118 (2021).
4. Chen, G., Zhou, H.*, Liu, B., Wang, Y., Zhao, J., Giancotti, F.*, Long, J.*, A Heterotrimeric SMARCB1-SMARCC2 Subcomplex is Required for the Assembly and Tumor Suppression Function of the BAF Chromatin-remodeling Complex, Cell Discov., 6:66, (2020).
5. Xie, Y., Zheng, M., Chu, X., Chen, Y., Xu, H., Wang, J., Zhou, H.*, Long, J.*, Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation, Nat. Commun., 9(1):3795 (2018).
6. Xu, H., Lin, Z., Li, F., Diao, W., Dong, C., Zhou, H., Xie, X., Wang, Z., Shen, Y.*, Long, J.*, Dimerization of elongator protein 1 is essential for Elongator complex assembly, Proc. Natl. Acad. Sci. USA, 112(34): 10697-10702 (2015).
7. Li, Y., Zhou, H., Li, F., Chan, S., Lin, Z., Wei, Z., Yang, Z., Guo, F., Lim, C., Xing, W., Shen, Y., Hong, W., Long, J.*, Zhang, M.*, Angiomotin binding-induced activation of Merlin/NF2 in the hippo signaling pathway, Cell Res., 25(7): 801-817 (2015).
8. Chu, X., Qin, X., Xu, H., Li, L., Wang, Z., Li, F., Xie, X., Zhou, H., Shen Y.*, Long, J.*, Structural insights into Paf1 complex assembly and histone binding, Nucleic Acids Res., 41(22): 10619-10629 (2013).
9. Zhang, X., Chu, X., Wang, L., Wang, H., Liang, G., Zhang, J., Long, J.*, Yang, Z.*, Rational design of a tetrameric Protein to enhance interactions between self-assembled fibers confers molecular hydrogels, Angew. Chem. Int. Ed., 51(18): 4388-4392 (2012).
10. Wang, Z., Yang, X., Chu, X., Zhang, J., Zhou, H., Shen, Y.*, Long, J.*, The structural basis for the oligomerization of the N-terminal domain of SATB1, Nucleic Acids Res., 40(9): 4193-4202 (2012).
